Macro- and Microvascular Function in Middle-Aged Individuals with Low Cardiovascular Disease Risk

Sunni Patel, Hala Shokr, Adam Greenstein, Doina Gherghel*, Roberto Pedrinelli (Editor)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To investigate the microvascular function in apparently healthy individuals showing signs of early macrovascular endothelial dysfunction. Methods: Healthy participants aged between 30–55 years were recruited for the present study. Baseline measurements included body-mass index (BMI), waist-to-hip ratio (WHR), 24-h blood pressure, as well as fasted venous glucose, triglycerides (TG) and cholesterol (HDL, LDL and total). Brachial artery reactivity was measured using the flow-mediated dilation (FMD) technique and retinal vessel reactivity was assessed by using the Dynamic Retinal Vessel Analyser (DVA) in all individuals. The enrolled participants were separated in two groups, based on either a reduced (group 1:
Original languageEnglish
Article number6962
Number of pages9
JournalJournal of Clinical Medicine
Volume11
Issue number23
Early online date25 Nov 2022
DOIs
Publication statusPublished - Dec 2022

Bibliographical note

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Keywords

  • microvascular function
  • retina
  • vascular endothelial
  • flow-mediated dilation

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