TY - JOUR
T1 - MARK-AGE biomarkers of ageing
AU - Bürkle, Alexander
AU - Moreno-Villanueva, María
AU - Bernhard, Jürgen
AU - Blasco, María
AU - Zondag, Gerben
AU - Hoeijmakers, Jan H.J.
AU - Toussaint, Olivier
AU - Grubeck-Loebenstein, Beatrix
AU - Mocchegiani, Eugenio
AU - Collino, Sebastiano
AU - Gonos, Efstathios S.
AU - Sikora, Ewa
AU - Gradinaru, Daniela
AU - Dollé, Martijn
AU - Salmon, Michel
AU - Kristensen, Peter
AU - Griffiths, Helen R.
AU - Libert, Claude
AU - Grune, Tilman
AU - Breusing, Nicolle
AU - Simm, Andreas
AU - Franceschi, Claudio
AU - Capri, Miriam
AU - Talbot, Duncan
AU - Caiafa, Paola
AU - Friguet, Bertrand
AU - Slagboom, P. Eline
AU - Hervonen, Antti
AU - Hurme, Mikko
AU - Aspinall, Richard
N1 - © 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.
PY - 2015/11
Y1 - 2015/11
N2 - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
AB - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
KW - ageing biomarkers
KW - human studies
KW - MARK-AGE
UR - http://www.scopus.com/inward/record.url?scp=84941698753&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2015.03.006
DO - 10.1016/j.mad.2015.03.006
M3 - Article
C2 - 25818235
SN - 1872-6216
VL - 151
SP - 2
EP - 12
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
ER -