Microporous polycaprolactone matrices for controlled drug delivery

H. I. Chang; Y. Perrie; A. G A Coombes

Microporous polycaprolactone matrices for controlled drug delivery

H. I. Chang^*, Y. Perrie, A. G A Coombes

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Conference publication

Abstract

The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm³ and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Publication status	Published - 1 Dec 2004
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: 17 May 2004 → 21 May 2004

Conference

Conference	Transactions - 7th World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	17/05/04 → 21/05/04

Cite this

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title = "Microporous polycaprolactone matrices for controlled drug delivery",

abstract = "The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm3 and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.",

author = "Chang, {H. I.} and Y. Perrie and Coombes, {A. G A}",

year = "2004",

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T1 - Microporous polycaprolactone matrices for controlled drug delivery

AU - Chang, H. I.

AU - Perrie, Y.

AU - Coombes, A. G A

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm3 and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.

AB - The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm3 and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.

UR - http://www.scopus.com/inward/record.url?scp=13844255623&partnerID=8YFLogxK

M3 - Conference publication

AN - SCOPUS:13844255623

SN - 1877040193

SN - 9781877040191

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -

Microporous polycaprolactone matrices for controlled drug delivery

Abstract

Conference

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