Abstract
Colistin has a physical mechanism of action. It damages membranes with a lethal effect and does not inhibit enzymes or sophisticated cellular systems. Colistin has a self-promoted uptake mechanism and ultimately targets the cytoplasmic membrane. It is bactericidal at low concentrations. Resistance rates are very low, although resistance is possible.
| Original language | English |
|---|---|
| Title of host publication | International Congress and Symposium Series - Royal Society of Medicine |
| Editors | D. Geddes |
| Place of Publication | London (UK) |
| Publisher | RSM Press |
| Pages | 2-8 |
| Number of pages | 7 |
| Volume | 258 |
| ISBN (Print) | 9781853155895 |
| Publication status | Published - 27 Aug 2004 |
Publication series
| Name | International Congress and Symposium Series of the Royal Society of Medicine |
|---|---|
| Publisher | Royal Society of Medicine Press Ltd |
| ISSN (Print) | 0142-2367 |
Keywords
- colistin
- resistance mechanisms