TY - CHAP
T1 - Modeling responses to respiratory house dust mite exposure
AU - Cates, E.
AU - Fattouh, R.
AU - Johnson, J.
AU - Llop-Guevara, A.
AU - Jordana, M.
PY - 2007
Y1 - 2007
N2 - House dust mite (HDM) is the most pervasive indoor aeroallergen source worldwide. Allergens derived from HDM are associated with sensitization and allergic asthma. Allergic asthma is an immunologically driven disease characterized by a Th2-polarized immune response, eosinophilic inflammation, airway hyperreactivity, and remodeling. Animal models of asthma utilizing ovalbumin (OVA) exposure have afforded us considerable insight with respect to the mediators and cell types involved in allergic airway inflammation. However, OVA preparations and HDM are two vastly different materials. This chapter is specifically concerned with modeling responses to HDM exposure in mice. These studies have furnished new information and unlocked new lines of inquiry regarding biological responses to common aeroallergens. The complexity of HDM as an allergen source, with its plethora of protein and nonprotein immunogenic components, may influence the mechanisms underlying sensitization, inflammation and remodeling. Here, we will discuss this issue, along with giving critical thought to the use of experimental models.
AB - House dust mite (HDM) is the most pervasive indoor aeroallergen source worldwide. Allergens derived from HDM are associated with sensitization and allergic asthma. Allergic asthma is an immunologically driven disease characterized by a Th2-polarized immune response, eosinophilic inflammation, airway hyperreactivity, and remodeling. Animal models of asthma utilizing ovalbumin (OVA) exposure have afforded us considerable insight with respect to the mediators and cell types involved in allergic airway inflammation. However, OVA preparations and HDM are two vastly different materials. This chapter is specifically concerned with modeling responses to HDM exposure in mice. These studies have furnished new information and unlocked new lines of inquiry regarding biological responses to common aeroallergens. The complexity of HDM as an allergen source, with its plethora of protein and nonprotein immunogenic components, may influence the mechanisms underlying sensitization, inflammation and remodeling. Here, we will discuss this issue, along with giving critical thought to the use of experimental models.
UR - http://www.scopus.com/inward/record.url?scp=35848957701&partnerID=8YFLogxK
UR - https://www.karger.com/Article/Abstract/107054
U2 - 10.1159/000107054
DO - 10.1159/000107054
M3 - Chapter
C2 - 17684332
AN - SCOPUS:35848957701
SN - 9783805583329
T3 - Contributions to Microbiology
SP - 42
EP - 67
BT - Models of Exacerbations in Asthma and COPD
A2 - Sjobring, U.
A2 - Taylor, J.D.
PB - Karger
ER -