Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs

Angelina I. Zherebtsova, Viktor V. Dremin, Irina N. Makovik, Evgeny A. Zherebtsov, Andrey V. Dunaev, Alexey Goltsov, Sergei G. Sokolovski, Edik U. Rafailov

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The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases. This paper is devoted to the development and application of the optical non-invasive diagnostic approach for the detection and evaluation of the severity of microcirculatory and metabolic disorders in rheumatic diseases and diabetes mellitus. The proposed methods include the joint use of laser Doppler flowmetry, absorption spectroscopy and fluorescence spectroscopy in combination with functional tests. This technique showed the high diagnostic importance for the detection of disturbances in peripheral microhaemodynamics. These methods have been successfully tested as additional diagnostic techniques in the field of rheumatology and endocrinology. The sensitivity and specificity of the proposed diagnostic procedures have been evaluated.
Original languageEnglish
Article number416
JournalFrontiers in Physiology
Issue numberMAR
Publication statusPublished - 16 Apr 2019

Bibliographical note

© 2019 Zherebtsova, Dremin, Makovik, Zherebtsov, Dunaev, Goltsov, Sokolovski and Rafailov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Funding: SS and ER were partially supported by Russian Science Foundation (Grant No. 18-15-00172). EZ kindly acknowledges for personal support from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement No. 703145 and Academy of Finland, grant No. 318281. AZ (regarding the experimental studies of the blood perfusion and skin temperature dynamics for functional diagnostics of intradermal finger vessels) was funded by the Russian Science Foundation (Grant No. 18-79-00237).


  • Diabetes mellitus
  • Fluorescence spectroscopy
  • Laser doppler flowmetry
  • Pulse oximetry
  • Rheumatic diseases
  • Skin thermometry
  • Tissue reflectance oximetry


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