Multiple system atrophy (MSA): Topographic distribution of the α-synuclein-associated pathological changes

R. A. Armstrong; N. J. Cairns; P. L. Lantos

doi:10.1016/j.parkreldis.2006.02.005

Multiple system atrophy (MSA): Topographic distribution of the α-synuclein-associated pathological changes

R. A. Armstrong^*, N. J. Cairns, P. L. Lantos

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

To study the topographic distribution of the pathology in multiple system atrophy (MSA). Pattern analysis was carried out using α-synuclein immunohistochemistry in 10 MSA cases. The glial cytoplasmic inclusions (GCI) were distributed randomly or in large clusters. The neuronal inclusions (NI) and abnormal neurons were distributed in regular clusters. Clusters of the NI and abnormal neurons were spatially correlated whereas the GCI were not spatially correlated with either the NI or the abnormal neurons. The data suggest that the GCI represent the primary change in MSA and the neuronal pathology develops secondary to the glial pathology.

Original language	English
Pages (from-to)	356-362
Number of pages	7
Journal	Parkinsonism and Related Disorders
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.parkreldis.2006.02.005
Publication status	Published - 1 Sept 2006

Keywords

Basal ganglia
Frontal cortex
Glial cytoplasmic inclusion (GCI)
Multiple system atrophy (MSA)
Neuronal inclusion (NI)
Spatial patterns

Access to Document

10.1016/j.parkreldis.2006.02.005

Cite this

@article{b60e4b53d3b34779a2f80111c343f855,

title = "Multiple system atrophy (MSA): Topographic distribution of the α-synuclein-associated pathological changes",

abstract = "To study the topographic distribution of the pathology in multiple system atrophy (MSA). Pattern analysis was carried out using α-synuclein immunohistochemistry in 10 MSA cases. The glial cytoplasmic inclusions (GCI) were distributed randomly or in large clusters. The neuronal inclusions (NI) and abnormal neurons were distributed in regular clusters. Clusters of the NI and abnormal neurons were spatially correlated whereas the GCI were not spatially correlated with either the NI or the abnormal neurons. The data suggest that the GCI represent the primary change in MSA and the neuronal pathology develops secondary to the glial pathology.",

keywords = "Basal ganglia, Frontal cortex, Glial cytoplasmic inclusion (GCI), Multiple system atrophy (MSA), Neuronal inclusion (NI), Spatial patterns",

author = "Armstrong, {R. A.} and Cairns, {N. J.} and Lantos, {P. L.}",

year = "2006",

month = sep,

day = "1",

doi = "10.1016/j.parkreldis.2006.02.005",

language = "English",

volume = "12",

pages = "356--362",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Multiple system atrophy (MSA)

T2 - Topographic distribution of the α-synuclein-associated pathological changes

AU - Armstrong, R. A.

AU - Cairns, N. J.

AU - Lantos, P. L.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - To study the topographic distribution of the pathology in multiple system atrophy (MSA). Pattern analysis was carried out using α-synuclein immunohistochemistry in 10 MSA cases. The glial cytoplasmic inclusions (GCI) were distributed randomly or in large clusters. The neuronal inclusions (NI) and abnormal neurons were distributed in regular clusters. Clusters of the NI and abnormal neurons were spatially correlated whereas the GCI were not spatially correlated with either the NI or the abnormal neurons. The data suggest that the GCI represent the primary change in MSA and the neuronal pathology develops secondary to the glial pathology.

AB - To study the topographic distribution of the pathology in multiple system atrophy (MSA). Pattern analysis was carried out using α-synuclein immunohistochemistry in 10 MSA cases. The glial cytoplasmic inclusions (GCI) were distributed randomly or in large clusters. The neuronal inclusions (NI) and abnormal neurons were distributed in regular clusters. Clusters of the NI and abnormal neurons were spatially correlated whereas the GCI were not spatially correlated with either the NI or the abnormal neurons. The data suggest that the GCI represent the primary change in MSA and the neuronal pathology develops secondary to the glial pathology.

KW - Basal ganglia

KW - Frontal cortex

KW - Glial cytoplasmic inclusion (GCI)

KW - Multiple system atrophy (MSA)

KW - Neuronal inclusion (NI)

KW - Spatial patterns

UR - http://www.scopus.com/inward/record.url?scp=33746894526&partnerID=8YFLogxK

UR - https://www.sciencedirect.com/science/article/pii/S135380200600037X?via%3Dihub

U2 - 10.1016/j.parkreldis.2006.02.005

DO - 10.1016/j.parkreldis.2006.02.005

M3 - Article

C2 - 16723266

SN - 1353-8020

VL - 12

SP - 356

EP - 362

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 6

ER -

Multiple system atrophy (MSA): Topographic distribution of the α-synuclein-associated pathological changes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this