Neuropathological differences between areas B17 and B18: implications for visual evoked responses in Alzheimer's disease

Richard A. Armstrong

doi:10.1159/000106732

Neuropathological differences between areas B17 and B18: implications for visual evoked responses in Alzheimer's disease

Richard A. Armstrong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The density of senile plaques (SP) and neurofibrillary tangles (NFT) was estimated at post-mortem in areas B17 and B18 of the visual cortex in 18 Alzheimer’s disease (AD) cases which varied in disease onset and duration. The density of SP in B17 and NFT in B17 and B18 declined significantly with age at death of the patient. The density of SP and NFT was greater in B18 than B17 but only in cases of earlier onset and shorter duration. The pathological differences between B17 and B18 could explain the visual evoked responses (VER) that have been reported in AD. However, the differences were small, and changes in the afferent pathways remain the most likely explanation for the VER in AD. © 1994 S. Karger AG, Basel.

Original language	English
Pages (from-to)	247-251
Number of pages	5
Journal	Dementia and Geriatric Cognitive Disorders
Volume	5
Issue number	5
DOIs	https://doi.org/10.1159/000106732
Publication status	Published - 1994

Keywords

Alzheimer's diseas
senile plaques
neurofibrillary tangles
visual evoked responses
visual cortex

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10.1159/000106732

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title = "Neuropathological differences between areas B17 and B18: implications for visual evoked responses in Alzheimer's disease",

abstract = "The density of senile plaques (SP) and neurofibrillary tangles (NFT) was estimated at post-mortem in areas B17 and B18 of the visual cortex in 18 Alzheimer{\textquoteright}s disease (AD) cases which varied in disease onset and duration. The density of SP in B17 and NFT in B17 and B18 declined significantly with age at death of the patient. The density of SP and NFT was greater in B18 than B17 but only in cases of earlier onset and shorter duration. The pathological differences between B17 and B18 could explain the visual evoked responses (VER) that have been reported in AD. However, the differences were small, and changes in the afferent pathways remain the most likely explanation for the VER in AD. {\textcopyright} 1994 S. Karger AG, Basel.",

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T1 - Neuropathological differences between areas B17 and B18: implications for visual evoked responses in Alzheimer's disease

AU - Armstrong, Richard A.

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AB - The density of senile plaques (SP) and neurofibrillary tangles (NFT) was estimated at post-mortem in areas B17 and B18 of the visual cortex in 18 Alzheimer’s disease (AD) cases which varied in disease onset and duration. The density of SP in B17 and NFT in B17 and B18 declined significantly with age at death of the patient. The density of SP and NFT was greater in B18 than B17 but only in cases of earlier onset and shorter duration. The pathological differences between B17 and B18 could explain the visual evoked responses (VER) that have been reported in AD. However, the differences were small, and changes in the afferent pathways remain the most likely explanation for the VER in AD. © 1994 S. Karger AG, Basel.

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KW - senile plaques

KW - neurofibrillary tangles

KW - visual evoked responses

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Neuropathological differences between areas B17 and B18: implications for visual evoked responses in Alzheimer's disease

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