TY - JOUR
T1 - Neurophysiology of CSWS-associated cognitive dysfunction
AU - Seri, Stefano
AU - Thai, Jade N.
AU - Brazzo, Daniela
AU - Pisani, Francesco
AU - Cerquiglini, Antonella
PY - 2009/8
Y1 - 2009/8
N2 - The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can "per se" produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.
AB - The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can "per se" produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.
KW - Landau-Kleffner syndrome
KW - CSWS
KW - Magnetoencephalography
KW - EEG-triggered fMRI
KW - auditory sensory processing
UR - http://www.scopus.com/inward/record.url?scp=68149125588&partnerID=8YFLogxK
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02216.x/abstract
U2 - 10.1111/j.1528-1167.2009.02216.x
DO - 10.1111/j.1528-1167.2009.02216.x
M3 - Article
C2 - 19682048
SN - 0013-9580
VL - 50
SP - 33
EP - 36
JO - Epilepsia
JF - Epilepsia
IS - Suppl. 7
ER -