Neuropsychiatric manifestations in inflammatory neuropathies: a systematic review

Yusuf A. Rajabally, Stefano Seri, Andrea E. Cavanna

Research output: Contribution to journalReview articlepeer-review


We conducted a systematic literature review on psychological and behavioral comorbidities in patients with inflammatory neuropathies. In Guillain-Barré syndrome (GBS), psychotic symptoms are reported during early stages in 30% of patients. Typical associations include mechanical ventilation, autonomic dysfunction, inability to communicate, and severe weakness. Anxiety and depression are frequent comorbidities. Anxiety may increase post-hospital admissions and be a predictor of mechanical ventilation. Post-traumatic stress disorder may affect up to 20% of ventilated patients. Sleep disturbances are common in early-stage GBS, affecting up to 50% of patients. In chronic inflammatory demyelinating polyradiculoneuropathy, memory and quality of sleep may be impaired. An independent link between depression and pre-treatment upper limb disability and ascites was reported in POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin) syndrome, with an association with early death. Hematological treatment of POEMS appears effective on depression. Published literature on psychological/behavioral manifestations in inflammatory neuropathies remains scarce, and further research is needed. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMuscle and Nerve
Issue number1
Early online date10 May 2016
Publication statusPublished - Jul 2016

Bibliographical note

This is the peer reviewed version of the following article: Rajabally, Y. A., Seri, S., & Cavanna, A. E. (2016). Neuropsychiatric manifestations in inflammatory neuropathies: a systematic review. Muscle & nerve, Early view, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.


  • chronic inflammatory demyelinating polyneuropathy
  • Guillain–Barré syndrome
  • inflammatory
  • neuropsychiatric
  • neuropathy
  • POEMS syndrome


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