Non-linear dynamics in transcriptional regulation: Biological logic gates

Till D. Frank, Miguel A.S. Cavadas, Lan K. Nguyen, Alex Cheong*

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter


Gene expression relies on the interaction of numerous transcriptional signals at the promoter to elicit a response—to read or not to read the genomic code, and if read, the strength of the read. The interplay of transcription factors can be viewed as nonlinear dynamics underlying the biological complexity. Here we analyse the regulation of the cyclooxygenase 2 promoter by NF-κB using thermostatistical and quantitative kinetic modelling and propose the presence of a genetic Boolean AND logic gate controlling the differential expression of cyclooxygenase 2 among species.

Original languageEnglish
Title of host publicationNonlinear Dynamics in Biological Systems
EditorsJ Carballido-Landeira, B Escribano
Number of pages20
ISBN (Electronic)978-3-319-33054-9
ISBN (Print)978-3-319-33053-2
Publication statusPublished - 21 Jul 2016

Publication series

NameSEMA SIMAI Springer Series
ISSN (Print)2199-3041
ISSN (Electronic)2199-305X


Dive into the research topics of 'Non-linear dynamics in transcriptional regulation: Biological logic gates'. Together they form a unique fingerprint.

Cite this