Numerical simulation of corneal transport processes

Long-Yuan Li, Brian Tighe

Research output: Contribution to journalArticlepeer-review


This paper presents a numerical study on the transport of ions and ionic solution in human corneas and the corresponding influences on corneal hydration. The transport equations for each ionic species and ionic solution within the corneal stroma are derived based on the transport processes developed for electrolytic solutions, whereas the transport across epithelial and endothelial membranes is modelled by using phenomenological equations derived from the thermodynamics of irreversible processes. Numerical examples are provided for both human and rabbit corneas, from which some important features are highlighted.
Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalJournal of the Royal Society Interface
Issue number7
Publication statusPublished - 22 Apr 2006


  • corneal swelling
  • hydration
  • ionic transport
  • electrolyte
  • thermodynamics


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