Optical fine needle biopsy in hepatocellular carcinoma mouse model

Elena Potapova, Ksenia Kandurova*, Valery Shupletsov, Evgeniya Seryogina, Viktor Dremin, Evgeny Zherebtsov, Alexander Alekseyev, Andrian Mamoshin, Yuri Ivanov, Dmitry Panchenkov, Andrey Dunaev

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


The paper describes the results of experimental studies using custom developed optical biopsy system for diagnostics in vivo during the procedure of fine needle aspiration biopsy. Experimental studies were conducted in laboratory mice with inoculated hepatocellular carcinoma. The measurements were carried out using fluorescence spectroscopy and diffuse reflectance spectroscopy methods to reveal metabolic and morphological changes in tissues. The results show that the developed approach is sensitive for cancer detection. Quantified differences in the maximum of fluorescence spectra and diffuse reflectance spectra between tumor and normal tissues were demonstrated and approved with morphological analysis.

Original languageEnglish
Article number113630V
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2 Apr 2020
EventTissue Optics and Photonics 2020 - None, France
Duration: 6 Apr 202010 Apr 2020

Bibliographical note

Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.


  • Diffuse reflectance spectroscopy
  • Fine needle aspiration biopsy
  • Fluorescence spectroscopy
  • Hepatocellular carcinoma
  • Liver cancer
  • Optical biopsy


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