Oxygen tension, H2S, and NO bioavailability: is there an interaction?

Gopi K. Kolluru; Priya K. Prasai; Amir M. Kaskas; Vijay Letchuman; Christopher B. Pattillo

doi:10.1152/japplphysiol.00365.2015

Oxygen tension, H₂S, and NO bioavailability: is there an interaction?

Gopi K. Kolluru, Priya K. Prasai, Amir M. Kaskas, Vijay Letchuman, Christopher B. Pattillo

Aston Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Molecular oxygen (O₂) is an essential component for survival and development. Variation in O₂ levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H₂S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H₂S are believed to mediate hypoxic responses and serve as O₂ chemosensors in biological systems. In this literature review, we briefly discuss NO and H₂S and their roles during hypoxia.

Original language	English
Pages (from-to)	263-270
Number of pages	8
Journal	Journal of Applied Physiology
Volume	120
Issue number	2
Early online date	17 Sept 2015
DOIs	https://doi.org/10.1152/japplphysiol.00365.2015
Publication status	Published - 15 Jan 2016

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http://jap.physiology.org/content/120/2/263

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title = "Oxygen tension, H2S, and NO bioavailability: is there an interaction?",

abstract = "Molecular oxygen (O2) is an essential component for survival and development. Variation in O2 levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H2S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H2S are believed to mediate hypoxic responses and serve as O2 chemosensors in biological systems. In this literature review, we briefly discuss NO and H2S and their roles during hypoxia.",

author = "Kolluru, {Gopi K.} and Prasai, {Priya K.} and Kaskas, {Amir M.} and Vijay Letchuman and Pattillo, {Christopher B.}",

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AU - Letchuman, Vijay

AU - Pattillo, Christopher B.

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AB - Molecular oxygen (O2) is an essential component for survival and development. Variation in O2 levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H2S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H2S are believed to mediate hypoxic responses and serve as O2 chemosensors in biological systems. In this literature review, we briefly discuss NO and H2S and their roles during hypoxia.

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JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

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ER -

Oxygen tension, H2S, and NO bioavailability: is there an interaction?

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Oxygen tension, H₂S, and NO bioavailability: is there an interaction?