P740 Hyperlipidaemia as a risk factor for breast cancer?

R Potluri, D Lavu, H Uppal, S Chandran

Research output: Contribution to journalConference abstractpeer-review


Purpose - Recent basic science research has suggested a plausible link between cholesterol and breast cancer.These studies provide a mechanistic biological pathway for the link between obesity and breast cancer.The findings raise numerous possibilities such as the potential role of statins in the treatment of breast cancer. Based on this research linking cholesterol and breast cancer, we investigated the link between hyperlipidaemia and breast cancer in our ACALM (Algorithm for Comorbidities, Associations, Length of stay and Mortality) study population of over 1 million patients.
Methods - Our research work is based on an anonymous clinical database of over 1 million patients covering numerous hospitals in Birmingham and Manchester, UK using the ACALM protocol . We have so far investigated the roles of risk factors and co-morbidities of mainly cardiovascular and psychiatric disease and published widely.We now investigated the risk of breast cancer with patients with and without hyperlipidaemia from our study population using a similar methodology and logistic regressio Results:Out of 664159 women there were 22938 patients with hyperlipidaemia (3.5%) and 9312patients with breast cancer. Out of the hyperlipidaemia patients, 530 patients developed breastcancer (2.3%) compared with 8782 patients developing breast cancer without hyperlipidaemia(1.4%). A logistic regression model accounting for time from first presentation to development ofbreast cancer showed that the presence of hyperlipidaemia increases the outcome of breast cancerby 1.64 times (95% C.I. 1.50-1.79).Conclusions:Whilst we appreciate numerous limitations of our methods, coupled with the main find-ings of the recent basic science research, our analysis further augments the case for the role of choles-terol in the development of breast cancer. Our data from a large clinical relevant sample furtherstrengthens the argument to prospectively trial statins in the management of breast cancer.
Original languageEnglish
Pages (from-to)S135.4-S135
Number of pages1
JournalCardiovascular Research
Issue numbersuppl 1
Publication statusPublished - 15 Jul 2014


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