Pentoxifylline and the behaviour of 29-month female mice

D. Myers, Richard A. Armstrong, C.U.M. Smith

Research output: Unpublished contribution to conferenceUnpublished Conference Paperpeer-review


The dimethyl-xanthine derivative pentoxifylline (PTX) increases blood flow through capillaries. In elderly humans the drug leads to improvement in a number of imapired neuropsychological parameters. We now report that oral administration to 29-month female mice (C57, black and tan) over six days induced four different patterns of behavioural reponse: (1) consistent improvement in grooming behaviour throughout the six day trial; (2) significant improvement in light/dark zone curiosity and curiosity towards a strange object on day three, which declined but remained significantly above pre-treatment levels at day 6; (3) an improvement in general activity which only becomes detectable on day six; (4) a significant improvement in rod-walking, rearing an shuttle-box crosses on day three which returned to pre-treatment levels by day 6. Age-related deficits in general activity, grooming and curiosity were completely eliminated by the drug - the mean group performance levels attained those seen in 9-12 month individuals of this strain.
Original languageEnglish
Publication statusUnpublished - 1987
EventFifth Meeting of the Brain Research Association - Edinburgh (UK)
Duration: 29 Mar 19871 Apr 1987


ConferenceFifth Meeting of the Brain Research Association
CityEdinburgh (UK)

Bibliographical note

Abstract appearing in Abstracts of the fifth meeting of the Brain Research Association. Edinburgh, Scotland, U.K., March 29-April 1, 1987. Neuroscience Letters, 29 (Suppl. 1), p.150.


  • dimethyl-xanthine derivative pentoxifylline
  • blood flow
  • imapired neuropsychological parameters


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