TY - JOUR
T1 - Poly(l-proline)-Stabilized Polypeptide Nanostructures via Ring-Opening Polymerization-Induced Self-Assembly (ROPISA
AU - Tinajero-Díaz, Ernesto
AU - Judge, Nicola
AU - Li, Bo
AU - Leigh, Thomas
AU - Murphy, Robert D.
AU - Topham, Paul D.
AU - Derry, Matthew J.
AU - Heise, Andreas
N1 - This publication is licensed under CC-BY 4.0. © 2024 The Authors. Published by American Chemical Society
PY - 2024/7/29
Y1 - 2024/7/29
N2 - Poly(proline) II helical motifs located at the protein–water interface stabilize the three-dimensional structures of natural proteins. Reported here is the first example of synthetic biomimetic poly(proline)-stabilized polypeptide nanostructures obtained by a straightforward ring-opening polymerization-induced self-assembly (ROPISA) process through consecutive N-carboxyanhydride (NCA) polymerization. It was found that the use of multifunctional 8-arm initiators is critical for the formation of nanoparticles. Worm-like micelles as well as spherical morphologies were obtained as confirmed by dynamic light scattering (DLS), transmission electron microscopy (TEM), and small angle X-ray scattering (SAXS). The loading of the nanostructures with dyes is demonstrated. This fast and open-vessel procedure gives access to amino acids-based nanomaterials with potential for applications in nanomedicine.
AB - Poly(proline) II helical motifs located at the protein–water interface stabilize the three-dimensional structures of natural proteins. Reported here is the first example of synthetic biomimetic poly(proline)-stabilized polypeptide nanostructures obtained by a straightforward ring-opening polymerization-induced self-assembly (ROPISA) process through consecutive N-carboxyanhydride (NCA) polymerization. It was found that the use of multifunctional 8-arm initiators is critical for the formation of nanoparticles. Worm-like micelles as well as spherical morphologies were obtained as confirmed by dynamic light scattering (DLS), transmission electron microscopy (TEM), and small angle X-ray scattering (SAXS). The loading of the nanostructures with dyes is demonstrated. This fast and open-vessel procedure gives access to amino acids-based nanomaterials with potential for applications in nanomedicine.
UR - https://pubs.acs.org/doi/10.1021/acsmacrolett.4c00400
UR - http://www.scopus.com/inward/record.url?scp=85199902108&partnerID=8YFLogxK
U2 - 10.1021/acsmacrolett.4c00400
DO - 10.1021/acsmacrolett.4c00400
M3 - Letter, comment/opinion or interview
SN - 2161-1653
VL - 13
SP - 1031
EP - 1036
JO - ACS Macro Letters
JF - ACS Macro Letters
ER -