Preformulation studies on grewia gum as a formulation excipient

Elijah I. Nep*, Barbara R. Conway

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Grewia gum is a naturally occurring polysaccharide which has potential as a pharmaceutical excipient. Differential scanning calorimetry and Fourier transform infrared (FT-IR) spectroscopy techniques were used to examine the thermal and molecular behaviours, respectively, of mixtures of grewia gum with cimetidine, ibuprofen or standard excipients, to assess potential interactions. No disappearance or broadening of the melting endotherm was seen with cimetidine or ibuprofen. Similarly, there was no interaction between grewia gum and the standard excipients tested. The results obtained using thermal analyses were supported by FT-IR analysis of the material mixtures. Grewia gum is an inert natural polymer which can be used alone or in combination with other excipients in the formulation of pharmaceutical dosage forms.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalJournal of Thermal Analysis and Calorimetry
Issue number1
Early online date17 Jul 2011
Publication statusPublished - Apr 2012


  • cimetidine
  • DSC
  • excipients
  • FT-IR
  • grewia gum
  • ibuprofen


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