TY - JOUR
T1 - Prevalence of anxiety symptomatology and diagnosis in syndromic intellectual disability: a systematic review and meta-analysis
AU - Edwards, Georgina
AU - Jones, Chris
AU - Pearson, Effie
AU - Royston, Rachel
AU - Oliver, Christopher
AU - Tarver, Joanne
AU - Crawford, Hayley
AU - Shelley, Lauren
AU - Waite, Jane
N1 - CC BY 4.0
Funding: This work was supported by The Baily Thomas Charitable Fund, grant number (5009-7975).
PY - 2022/7
Y1 - 2022/7
N2 - Individuals with syndromic intellectual disability are at increased risk of experiencing anxiety. Comparing prevalence estimates of anxiety will allow the identification of at-risk groups and inform causal pathways of anxiety. No known study has explored estimates of anxiety symptomatology and diagnosis, including specific anxiety profiles, across groups whilst accounting for methodological quality of studies. This systematic review and meta-analysis aimed to fill this gap. Prior to review completion, methodology and analysis plans were registered and documented in a protocol (CRD42019123561). Data from 83 papers, involving a pooled sample of 13,708 across eight syndromes were synthesised using a random effects model. Anxiety prevalence ranged from 9% (95% CI: 4-14) in Down syndrome to 73% in Rett syndrome (95% CI: 70-77). Anxiety prevalence across syndromic intellectual disability was higher than for intellectual disability of mixed aetiology and general population estimates. Substantial variability between syndromes identified groups at higher risk than others. The identification of high-risk groups is crucial for early intervention, allowing us to refine models of risk and identify divergent profiles.
AB - Individuals with syndromic intellectual disability are at increased risk of experiencing anxiety. Comparing prevalence estimates of anxiety will allow the identification of at-risk groups and inform causal pathways of anxiety. No known study has explored estimates of anxiety symptomatology and diagnosis, including specific anxiety profiles, across groups whilst accounting for methodological quality of studies. This systematic review and meta-analysis aimed to fill this gap. Prior to review completion, methodology and analysis plans were registered and documented in a protocol (CRD42019123561). Data from 83 papers, involving a pooled sample of 13,708 across eight syndromes were synthesised using a random effects model. Anxiety prevalence ranged from 9% (95% CI: 4-14) in Down syndrome to 73% in Rett syndrome (95% CI: 70-77). Anxiety prevalence across syndromic intellectual disability was higher than for intellectual disability of mixed aetiology and general population estimates. Substantial variability between syndromes identified groups at higher risk than others. The identification of high-risk groups is crucial for early intervention, allowing us to refine models of risk and identify divergent profiles.
KW - Anxiety
KW - Intellectual disability
KW - Meta-analysis
KW - Prevalence
KW - Review
KW - Syndromes
UR - https://www.sciencedirect.com/science/article/pii/S0149763422002081?via%3Dihub
UR - http://www.scopus.com/inward/record.url?scp=85131664662&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2022.104719
DO - 10.1016/j.neubiorev.2022.104719
M3 - Review article
SN - 0149-7634
VL - 138
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 104719
ER -