TY - JOUR
T1 - Progressive supranuclear palsy (PSP)
T2 - A quantitative study of the pathological changes in cortical and subcortical regions of eight cases
AU - Armstrong, Richard A.
AU - Lantos, Peter L.
AU - Cairns, Nigel J.
PY - 2007/12
Y1 - 2007/12
N2 - In eight cases of progressive supranuclear palsy (PSP), neurofibrillary tangles (NFT) were numerous in the substantia nigra (SN), red nucleus (RN), locus caeruleus (LC), pontine nuclei (PN), and inferior olivary nucleus (ION) and abnormally enlarged neurons (EN) in the ION, LC and PN. Loss of Purkinje cells was evident in the cerebellum. Tufted astrocytes (TA) were abundant in the striatum, SN and RN and glial inclusions ('coiled bodies') (GI) in the midbrain (SN, RN) and pons (LC). Neuritic plaques were frequent in one case. NFT, GI, and TA densities were uncorrelated in most areas. NFT and EN densities were positively correlated in the midbrain and surviving neurons and disease duration in several areas. These results suggest: 1) predominantly subcortical pathology in PSP with widespread NFT while TA and GI have a more localized distribution, 2) little correlation between neuronal and glial pathologies, and 3) shorter duration cases may be more likely to develop cortical pathology. © 2007 Springer-Verlag.
AB - In eight cases of progressive supranuclear palsy (PSP), neurofibrillary tangles (NFT) were numerous in the substantia nigra (SN), red nucleus (RN), locus caeruleus (LC), pontine nuclei (PN), and inferior olivary nucleus (ION) and abnormally enlarged neurons (EN) in the ION, LC and PN. Loss of Purkinje cells was evident in the cerebellum. Tufted astrocytes (TA) were abundant in the striatum, SN and RN and glial inclusions ('coiled bodies') (GI) in the midbrain (SN, RN) and pons (LC). Neuritic plaques were frequent in one case. NFT, GI, and TA densities were uncorrelated in most areas. NFT and EN densities were positively correlated in the midbrain and surviving neurons and disease duration in several areas. These results suggest: 1) predominantly subcortical pathology in PSP with widespread NFT while TA and GI have a more localized distribution, 2) little correlation between neuronal and glial pathologies, and 3) shorter duration cases may be more likely to develop cortical pathology. © 2007 Springer-Verlag.
KW - basal ganglia
KW - frontal cortex
KW - glial inclusions (GI)
KW - neuritic plaques
KW - neurofibrillary tangles (NFT)
KW - progressive supranuclear palsy (PSP)
KW - tufted astrocytes (TA)
UR - http://www.scopus.com/inward/record.url?scp=36749068856&partnerID=8YFLogxK
UR - http://www.springerlink.com/content/hx21ww5881v66016/?p=3d4f9c77ca4c4e61b66b211e482ac0c9&pi=0
U2 - 10.1007/s00702-007-0796-3
DO - 10.1007/s00702-007-0796-3
M3 - Article
C2 - 17680229
SN - 0300-9564
VL - 114
SP - 1569
EP - 1577
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 12
ER -