Abstract
We present radioprotective, antiglycating, and photoprotective properties of a water-soluble C60 fullerene derivative with L-arginine (C60-Arg) and composite films based on collagen containing C60-Arg. The synthesis of these materials is described. The identification of the synthesised materials was carried out using modern physicochemical methods of analysis. The physicochemical properties of aqueous solutions of C60-Arg, such as, particle size distribution, zeta potentials, distribution coefficient in the octan-1-ol–water system were measured. The computer simulation of the process of C60-Arg association in aqueous and isotonic solutions was carried out using Molecular Dynamics. Composite films based on collagen containing C60-Arg demonstrate significant improvement in mechanical properties, cell adhesion, and cell proliferation when the nano-modifier is added. This shows high potential for the use of the C60-Arg adduct in biomedicine.
Original language | English |
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Article number | 124702 |
Number of pages | 14 |
Journal | Journal of Molecular Liquids |
Volume | 401 |
DOIs | |
Publication status | Published - 1 May 2024 |
Bibliographical note
Copyright © 2024, Elsevier. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ This item is embargoed for 12 months in compliance with EPSRC funding.Data Access Statement
Data will be made available on requestSupplementary material to this article can be found online at https://doi.org/10.1016/j.molliq.2024.124702
Keywords
- Collagen
- Fullerene
- Molecular Dynamics
- Photoprotector
- Radioprotector