Proteoglycan analogues for ophthalmic and orthopaedic applications

Brian Tighe, Jane Bramhill, Darren Campbell

Research output: Contribution to journalArticlepeer-review


The successful development of biomaterials is increasingly influenced by biomimesis essentially the use of biological structures as design templates. This approach has been used here in the design of injectable systems for the nucleus of the intervertebral disc, corneal inlays and intraocular lenses (IOLs). The strategy is based on the use of C-linked sulphonates to mimic the O-linked sulphate groups that are the hydration drivers in proteoglycans. The elastic modulus of the materials can be tailored for specific applications.
Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalAdvanced Materials Research
Publication statusPublished - 25 Apr 2012


  • elastic modulus
  • sulphonates
  • hydrogel


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