RAMPs as drug targets

Patrick M. Sexton; David R. Poyner; John Simms; Arthur Christopoulos; Debbie L. Hay

doi:10.1007/978-1-4614-2364-5_6

RAMPs as drug targets

Patrick M. Sexton, David R. Poyner, John Simms, Arthur Christopoulos, Debbie L. Hay

Research output: Contribution to journal › Article

Abstract

The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache.

Original language	English
Pages (from-to)	61-74
Number of pages	14
Journal	Advances in Experimental Medicine and Biology
Volume	744
DOIs	https://doi.org/10.1007/978-1-4614-2364-5_6
Publication status	Published - 2012

Keywords

receptor activity-modifying proteins
G-protein-coupled receptors
signal transduction

Access to Document

10.1007/978-1-4614-2364-5_6

Cite this

@article{c89560eb08714872af835b6134200b03,

title = "RAMPs as drug targets",

abstract = "The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache.",

keywords = "receptor activity-modifying proteins, G-protein-coupled receptors, signal transduction",

author = "Sexton, {Patrick M.} and Poyner, {David R.} and John Simms and Arthur Christopoulos and Hay, {Debbie L.}",

year = "2012",

doi = "10.1007/978-1-4614-2364-5_6",

language = "English",

volume = "744",

pages = "61--74",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

publisher = "Springer",

}

TY - JOUR

T1 - RAMPs as drug targets

AU - Sexton, Patrick M.

AU - Poyner, David R.

AU - Simms, John

AU - Christopoulos, Arthur

AU - Hay, Debbie L.

PY - 2012

Y1 - 2012

N2 - The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache.

AB - The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache.

KW - receptor activity-modifying proteins

KW - G-protein-coupled receptors

KW - signal transduction

UR - http://www.scopus.com/inward/record.url?scp=84859791351&partnerID=8YFLogxK

UR - http://www.springerlink.com/content/m707r27l05l40w10/

U2 - 10.1007/978-1-4614-2364-5_6

DO - 10.1007/978-1-4614-2364-5_6

M3 - Article

C2 - 22434108

SN - 0065-2598

VL - 744

SP - 61

EP - 74

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

RAMPs as drug targets

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

RAMPs and CGRP receptors

Cite this