RAMPs as drug targets

Patrick M. Sexton, David R. Poyner, John Simms, Arthur Christopoulos, Debbie L. Hay

Research output: Contribution to journalArticle


The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache.
Original languageEnglish
Pages (from-to)61-74
Number of pages14
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 2012


  • receptor activity-modifying proteins
  • G-protein-coupled receptors
  • signal transduction


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