TY - JOUR
T1 - Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers
AU - Gan, Li
AU - Wang, Jing
AU - Jiang, Min
AU - Bartlett, Hannah
AU - Ouyang, Defang
AU - Eperjesi, Frank
AU - Liu, Jianping
AU - Yong, Gan
PY - 2013/3
Y1 - 2013/3
N2 - Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.
AB - Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.
UR - http://www.scopus.com/inward/record.url?scp=84874679837&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2012.10.005
DO - 10.1016/j.drudis.2012.10.005
M3 - Article
SN - 1359-6446
VL - 18
SP - 290
EP - 297
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 5-6
ER -