Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers

Li Gan, Jing Wang, Min Jiang, Hannah Bartlett, Defang Ouyang, Frank Eperjesi, Jianping Liu, Gan Yong

Research output: Contribution to journalArticlepeer-review


Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.
Original languageEnglish
Pages (from-to)290-297
Number of pages8
JournalDrug Discovery Today
Issue number5-6
Early online date22 Oct 2012
Publication statusPublished - Mar 2013


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