Abstract
Introduction: The density of diffuse, primitive and classic beta-amyloid (Abeta) deposits and blood vessels was studied in nine cases of sporadic Alzheimer's disease (SAD) and 10 cases of familial Alzheimer's disease (FAD) including two cases with amyloid precursor protein (APP) mutations (APP717, Val - Ile).
Materials and Methods: Sections of frontal cortex stained for Abeta12-28 counterstained with collagen type IV antiserum. Densities measured along the upper cortex in 64-128, 1000 x 200 micron continuous sample fields.
Results: The density of diffuse and primitive deposits was not correlated with blood vessels in FAD or SAD. The density of the classic deposits was positively correlated with the larger diameter (> 10 micron) blood vessels in all SAD cases and weakly correlated with blood vessel in three non-APP FAD cases. Conclusions: Blood vessels are less important in the formation of classic Abeta deposits in FAD compared with SAD.
| Original language | English |
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| Pages | 8-8 |
| Number of pages | 1 |
| Publication status | Published - 1994 |
| Event | 91st Meeting of British Neuropathological Society - London (UK) Duration: 11 Jan 1996 → 12 Jan 1996 |
Conference
| Conference | 91st Meeting of British Neuropathological Society |
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| City | London (UK) |
| Period | 11/01/96 → 12/01/96 |
Keywords
- density
- beta-amyloid
- Abeta
- Alzheimer's disease
- amyloid precursor protein mutations