Retinal microvascular dysfunction occurs similarly in Alzheimer's disease and primary open angle glaucoma patients

Stephanie Mroczkowska; Alexandra Benavente-Pérez; Sunni R. Patel; Anil Negi; Velota Sung; Peter Bentham; Doina Gherghel

Abstract

Purpose: The exact nature of the relationship between Alzheimer’s disease (AD) and primary open angle glaucoma (POAG) is still the subject of debate. One factor attributed to the aetiology of both conditions is vascular dysfunction. This study aimed to investigate the similarities and differences in retinal microvascular function between mild AD patients, early stage POAG patients and healthy controls

Methods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 22 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markers

Results: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p=0.014), which was not replicated in the healthy age and cardiovascular risk matched controls (p>0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p=0.001)

Conclusions: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. These comparable signs may reflect similarities in the pathophysiological processes that occur in the development of both conditions

Original language	English
Pages (from-to)	2763
Number of pages	1
Journal	Investigative Ophthalmology and Visual Science
Volume	56
Issue number	7
Publication status	Published - 30 Jun 2015
Event	ARVO 2015 Annual Meeting : Powerful Connections: Vision Research and Online Networking - Colorado Convention Center (CCC), Denver, CO, United States Duration: 2 May 2015 → 7 May 2015

Bibliographical note

ARVO 2015 Annual Meeting : Powerful Connections: Vision Research and Online Networking, 2-7 May 2015, Denver, CO, United States.

Access to Document

http://iovs.arvojournals.org/article.aspx?articleid=2332563

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Research output: Contribution to journal › Conference abstract › peer-review

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Research output: Contribution to journal › Conference abstract › peer-review

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Research output: Contribution to journal › Conference abstract › peer-review

Open Access

Cite this

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title = "Retinal microvascular dysfunction occurs similarly in Alzheimer's disease and primary open angle glaucoma patients",

abstract = "Purpose: The exact nature of the relationship between Alzheimer{\textquoteright}s disease (AD) and primary open angle glaucoma (POAG) is still the subject of debate. One factor attributed to the aetiology of both conditions is vascular dysfunction. This study aimed to investigate the similarities and differences in retinal microvascular function between mild AD patients, early stage POAG patients and healthy controlsMethods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 22 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markersResults: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p=0.014), which was not replicated in the healthy age and cardiovascular risk matched controls (p>0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p=0.001)Conclusions: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. These comparable signs may reflect similarities in the pathophysiological processes that occur in the development of both conditions",

author = "Stephanie Mroczkowska and Alexandra Benavente-P{\'e}rez and Patel, {Sunni R.} and Anil Negi and Velota Sung and Peter Bentham and Doina Gherghel",

note = "ARVO 2015 Annual Meeting : Powerful Connections: Vision Research and Online Networking, 2-7 May 2015, Denver, CO, United States.; ARVO 2015 Annual Meeting : Powerful Connections: Vision Research and Online Networking, ARVO 2015 ; Conference date: 02-05-2015 Through 07-05-2015",

year = "2015",

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journal = "Investigative Ophthalmology and Visual Science",

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number = "7",

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T1 - Retinal microvascular dysfunction occurs similarly in Alzheimer's disease and primary open angle glaucoma patients

AU - Mroczkowska, Stephanie

AU - Benavente-Pérez, Alexandra

AU - Patel, Sunni R.

AU - Negi, Anil

AU - Sung, Velota

AU - Bentham, Peter

AU - Gherghel, Doina

N1 - ARVO 2015 Annual Meeting : Powerful Connections: Vision Research and Online Networking, 2-7 May 2015, Denver, CO, United States.

PY - 2015/6/30

Y1 - 2015/6/30

N2 - Purpose: The exact nature of the relationship between Alzheimer’s disease (AD) and primary open angle glaucoma (POAG) is still the subject of debate. One factor attributed to the aetiology of both conditions is vascular dysfunction. This study aimed to investigate the similarities and differences in retinal microvascular function between mild AD patients, early stage POAG patients and healthy controlsMethods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 22 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markersResults: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p=0.014), which was not replicated in the healthy age and cardiovascular risk matched controls (p>0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p=0.001)Conclusions: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. These comparable signs may reflect similarities in the pathophysiological processes that occur in the development of both conditions

AB - Purpose: The exact nature of the relationship between Alzheimer’s disease (AD) and primary open angle glaucoma (POAG) is still the subject of debate. One factor attributed to the aetiology of both conditions is vascular dysfunction. This study aimed to investigate the similarities and differences in retinal microvascular function between mild AD patients, early stage POAG patients and healthy controlsMethods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 22 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markersResults: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p=0.014), which was not replicated in the healthy age and cardiovascular risk matched controls (p>0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p=0.001)Conclusions: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. These comparable signs may reflect similarities in the pathophysiological processes that occur in the development of both conditions

M3 - Conference abstract

SN - 1552-5783

VL - 56

SP - 2763

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 7

T2 - ARVO 2015 Annual Meeting

Y2 - 2 May 2015 through 7 May 2015

ER -

Retinal microvascular dysfunction occurs similarly in Alzheimer's disease and primary open angle glaucoma patients

Abstract

Bibliographical note

Access to Document

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Research output

Accommodative response to electrical stimulation of the sclera of peripheral cornea in cats and porcines

Can aberrometry provide rapid and reliable measures of subjective depth of focus following multifocal intraocular lens implantation?

Ciliary muscle morphology in emmetropia and ocular biometric correlates

Cite this