Abstract
Rho GTPases are a globular, monomeric group of small signaling G-protein molecules. Rho-associated protein kinase/Rho-kinase (ROCK) is a downstream effector protein of the Rho GTPase. Rho-kinases are the potential therapeutic targets in the treatment of cardiovascular diseases. Here, we have primarily discussed the intriguing roles of ROCK in cardiovascular health in relation to nitric oxide signaling. Further, we highlighted the biphasic effects of Y-27632, a ROCK inhibitor under shear stress, which acts as an agonist of nitric oxide production in endothelial cells. The biphasic effects of this inhibitor raised the question of safety of the drug usage in treating cardiovascular diseases.
Original language | English |
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Pages (from-to) | 45-54 |
Number of pages | 10 |
Journal | Nitric Oxide |
Volume | 43 |
Early online date | 6 Sept 2014 |
DOIs | |
Publication status | Published - 1 Dec 2014 |
Keywords
- amides
- drug delivery systems
- rho-associated kinases
- nitric oxide
- protein kinase inhibitors
- pyridines
- signal transduction
- vascular diseases