Role of hydrogen sulfide in the female reproductive tract

Ray J. Carson, Justin C. Konje

Research output: Contribution to journalArticlepeer-review


It is well established that hydrogen sulfide (H 2S) has a signaling role in the body. So far it has been shown that H 2S is produced by intra-uterine tissues in the pregnant rat and the human placenta. Two main enzymes responsible for H 2S production, cystathionine- synthase and cystathionine-lyase, have been demonstrated in the pregnant and nonpregnant uterus, fetal membranes and placenta in the rat, and in human placenta. H 2S donors have been shown to inhibit contraction of the pregnant rat uterus. H 2S could play a role in maintaining uterine quiescence during pregnancy, as an oxygen sensor and vasodilator in the placenta, or as an anti-inflammatory. More research is required in this area to elucidate the roles of H 2S in the female reproductive tract and its mechanisms of action.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalExpert Review of Obstetrics and Gynecology
Issue number2
Publication statusPublished - 2010


  • fetal membranes
  • hydrogen sulfide
  • myometrium
  • placenta
  • reproduction
  • uterus


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