SERF: a program for accessible surface area calculations

Darren R. Flower

Research output: Contribution to journalArticle


The program SERF has been designed to facilitate the greater use of accessible surface area calculations in the analysis of protein structure, including analysis of surface area changes on binding and complexation. For comparative purposes, the program implements a number of alternative methods for calculating surface areas, including those that approximate residues by single spheres. Algorithmic details, comparative performance, and the software implementation of SERF are discussed
Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalJournal of Molecular Graphics and Modelling
Issue number4
Publication statusPublished - Aug 1997


  • molecular surfaces
  • accessible surface area
  • macromolecular complexation
  • sphere packing


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