Serum neopterin levels and gallium transferrin binding in Parkinson's disease

S.J. Winsper; Richard A. Armstrong; H. Pall; D. Fuchs; J.A. Blair

Serum neopterin levels and gallium transferrin binding in Parkinson's disease

S.J. Winsper, Richard A. Armstrong, H. Pall, D. Fuchs, J.A. Blair

Research output: Unpublished contribution to conference › Poster › peer-review

Abstract

The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.

Original language	English
Publication status	Published - 1994
Event	Brain Research Association Conference - Southampton (UK) Duration: 11 Apr 1994 → 14 Apr 1994

Conference

Conference	Brain Research Association Conference
City	Southampton (UK)
Period	11/04/94 → 14/04/94

Bibliographical note

Abstract appearing in Brain Res Assoc Abstr 11:P48.

Keywords

unconjugated pterin neopterin
macrophages
interferon-gamma
cellular immune response
Parkinson's disease

Cite this

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title = "Serum neopterin levels and gallium transferrin binding in Parkinson's disease",

abstract = "The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.",

keywords = "unconjugated pterin neopterin, macrophages, interferon-gamma, cellular immune response, Parkinson's disease",

author = "S.J. Winsper and Armstrong, {Richard A.} and H. Pall and D. Fuchs and J.A. Blair",

note = "Abstract appearing in Brain Res Assoc Abstr 11:P48.; Brain Research Association Conference ; Conference date: 11-04-1994 Through 14-04-1994",

year = "1994",

language = "English",

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TY - CONF

T1 - Serum neopterin levels and gallium transferrin binding in Parkinson's disease

AU - Winsper, S.J.

AU - Armstrong, Richard A.

AU - Pall, H.

AU - Fuchs, D.

AU - Blair, J.A.

N1 - Abstract appearing in Brain Res Assoc Abstr 11:P48.

PY - 1994

Y1 - 1994

N2 - The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.

AB - The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.

KW - unconjugated pterin neopterin

KW - macrophages

KW - interferon-gamma

KW - cellular immune response

KW - Parkinson's disease

M3 - Poster

T2 - Brain Research Association Conference

Y2 - 11 April 1994 through 14 April 1994

ER -

Serum neopterin levels and gallium transferrin binding in Parkinson's disease

Abstract

Conference

Bibliographical note

Keywords

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