Single-cell analysis for bioprocessing

Hu Zhang, Xiaolin Cui, Jingxiu Bi, Sheng Dai, Haitao Ye

    Research output: Contribution to journalSpecial issuepeer-review


    Cell population heterogeneity has attracted great interest for understanding the individual cellular performances in their response to external stimuli and in the production of targeted products. Physical characterization of single cells and analysis of dynamic gene expression, synthesized proteins, and cellular metabolites from one single cell are reviewed. Advanced techniques have been developed to achieve high-throughput and ultrahigh resolution or sensitivity. Single cell capture methods are discussed as well. How to make use of cellular heterogeneities for maximizing cellular productivity is still in the infant stage, and control strategies will be formulated after the causes for heterogeneity have been elucidated.

    Original languageEnglish
    Pages (from-to)582-592
    Number of pages11
    JournalEngineering in Life Sciences
    Issue number6
    Early online date14 Jul 2015
    Publication statusPublished - Sept 2015

    Bibliographical note



    • gene expression
    • population heterogeneity
    • protein expression
    • single-cell analysis
    • single-cell isolation


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