TY - JOUR
T1 - Spatial topography of the neurofibrillary tangles in cortical and subcortical regions in progressive supranuclear palsy
AU - Armstrong, Richard A.
AU - Lantos, Peter L.
AU - Cairns, Nigel J.
PY - 2007/2
Y1 - 2007/2
N2 - Objective: To study the topography of neurofibrillary tangles (NFT) in cortical and subcortical areas in progressive supranuclear palsy (PSP). Methods: Pattern analysis was carried out on tau-positive NFT in eight PSP cases. Results: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas. Conclusion: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies. © 2006 Elsevier Ltd. All rights reserved.
AB - Objective: To study the topography of neurofibrillary tangles (NFT) in cortical and subcortical areas in progressive supranuclear palsy (PSP). Methods: Pattern analysis was carried out on tau-positive NFT in eight PSP cases. Results: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas. Conclusion: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies. © 2006 Elsevier Ltd. All rights reserved.
KW - cerebral cortex
KW - cortico-cortical pathways
KW - neurofibrillary tangles (NFT)
KW - progressive supranuclear palsy (PSP)
KW - spatial pattern
KW - subcortical regions
UR - http://www.scopus.com/inward/record.url?scp=33846444763&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2006.07.004
DO - 10.1016/j.parkreldis.2006.07.004
M3 - Article
C2 - 17046313
SN - 1353-8020
VL - 13
SP - 50
EP - 54
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 1
ER -