TY - JOUR
T1 - Spatially congruent negative BOLD responses to different stimuli do not summate in visual cortex
AU - Wilson, Ross
AU - Thomas, Andrea
AU - Mayhew, Stephen D.
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/9/1
Y1 - 2020/9/1
N2 - The negative BOLD response (NBR) is a prevalent feature of brain activity during sensory and cognitive tasks. It is thought to reflect suppression or deactivation of cortical areas unrequired for task performance, but much remains to be understood regarding its response properties and generative pathways. Here we study a unique property of sensory cortex NBR that most distinguishes it from positive BOLD responses (PBR), its appearance in a single location due to different stimuli. We investigate whether such NBR are additive, as a means of studying whether stimulus driven NBR arise via a single or multiple pathways. During fMRI, subject's passively viewed separate checkerboard stimulation of the foveal and middle-eccentricity areas of the left visual field and a third condition that stimulated both areas concurrently. PBR was observed in the contralateral primary visual cortex and NBR was seen throughout the ipsilateral cortex as well as in contralateral regions superior and anterior to the PBR. Strong spatial overlap of NBRs to all three conditions was observed. We found that neither PBR nor NBR were additive. NBR amplitudes to combined stimuli were equal to those of the strongest (foveal) stimulus alone, despite the mid-eccentricity stimulus inducing substantial NBR on its own. The lack of summation of NBRs, both in the same and opposite hemispheres to the PBR, suggests that they arise from a single pathway. Our findings suggest that although individual stimuli each exert a separate inhibitory effect on non-stimulated regions, once in combination these effects operate as a binary system. Deactivation of a given visual area is driven by a single signal, representing only the largest of the contributing sources.
AB - The negative BOLD response (NBR) is a prevalent feature of brain activity during sensory and cognitive tasks. It is thought to reflect suppression or deactivation of cortical areas unrequired for task performance, but much remains to be understood regarding its response properties and generative pathways. Here we study a unique property of sensory cortex NBR that most distinguishes it from positive BOLD responses (PBR), its appearance in a single location due to different stimuli. We investigate whether such NBR are additive, as a means of studying whether stimulus driven NBR arise via a single or multiple pathways. During fMRI, subject's passively viewed separate checkerboard stimulation of the foveal and middle-eccentricity areas of the left visual field and a third condition that stimulated both areas concurrently. PBR was observed in the contralateral primary visual cortex and NBR was seen throughout the ipsilateral cortex as well as in contralateral regions superior and anterior to the PBR. Strong spatial overlap of NBRs to all three conditions was observed. We found that neither PBR nor NBR were additive. NBR amplitudes to combined stimuli were equal to those of the strongest (foveal) stimulus alone, despite the mid-eccentricity stimulus inducing substantial NBR on its own. The lack of summation of NBRs, both in the same and opposite hemispheres to the PBR, suggests that they arise from a single pathway. Our findings suggest that although individual stimuli each exert a separate inhibitory effect on non-stimulated regions, once in combination these effects operate as a binary system. Deactivation of a given visual area is driven by a single signal, representing only the largest of the contributing sources.
UR - http://www.scopus.com/inward/record.url?scp=85085271311&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S1053811920303773?via%3Dihub
U2 - 10.1016/j.neuroimage.2020.116891
DO - 10.1016/j.neuroimage.2020.116891
M3 - Article
C2 - 32438052
AN - SCOPUS:85085271311
SN - 1053-8119
VL - 218
JO - NeuroImage
JF - NeuroImage
M1 - 116891
ER -