Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells

Keyphrases

• Salsolinol 100%
• 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) 100%
• Neurotoxicity 100%
• SH-SY5Y Cells 100%
• Catecholamines 40%
• Noradrenaline 30%
• IC50 Value 30%
• Dopamine 20%
• Uptake-1 20%
• Recognition Site 10%
• IC50 10%
• Protein Kinase 10%
• Cytotoxicity 10%
• Lactate Dehydrogenase Release 10%
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide 10%
• Neuroblastoma SH-SY5Y Cells 10%
• Monoamine Oxidase Inhibitors 10%
• 1-methyl-4-phenylpyridinium 10%
• MTT Reduction 10%
• Toxicity Mechanism 10%
• Bioactivation 10%
• Carbachol 10%
• Cytotoxicity in Vitro 10%
• Free Radical Damage 10%
• Cyclic GMP 10%
• Nisoxetine 10%
• Membrane-based 10%
• Imipramine 10%
• Monoamine Oxidase A (MAO-A) 10%
• Na + 10%
• Antioxidant 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Neurotoxicity 100%
• Salsolinol 100%
• Catecholamine 33%
• IC50 25%
• Noradrenalin 25%
• Cytotoxicity 16%
• Free Radical 8%
• Amine Oxidase (Flavin Containing) 8%
• Potassium Ion 8%
• Protein Kinase C 8%
• Monoamine Oxidase Inhibitor 8%
• Lactate Dehydrogenase 8%
• Nisoxetine 8%
• Bioactivation 8%
• 3 (4,5 Dimethyl 2 Thiazolyl) 2,5 Diphenyltetrazolium Bromide 8%
• 1 Methyl 4 Phenylpyridinium 8%
• Imipramine 8%
• Carbachol 8%
• Antioxidant 8%
• Neuroblastoma 8%
• Sodium Ion 8%
• EC50 8%