Synthesis, evaluation and incorporation into liposomes of 4-functionalised-2,5-diphenyloxazole derivatives for application in scintillation proximity assays

Mark C. McCairn, Steven J. Culliford, Roland Z. Kozlowski, Andrew J. Sutherland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The preparation of a series of 4-functionalised-2,5-diphenyloxazoles is described. The scintillating efficiency of each of these 'scintilipid' molecules has been evaluated in the presence of ionising radiation. Each 'scintilipid' has been assessed for the ability to assemble, with other lipids, into liposomes, under a variety of preparative conditions. Each liposomal preparation has been monitored for the ability to scintillate in the presence of ionising radiation. The optimal 'scintilipid', both in terms of effective liposomal formation and scintillation efficiency, has been determined.

Original languageEnglish
Pages (from-to)2163-2166
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number10
DOIs
Publication statusPublished - 1 Mar 2004

Bibliographical note

Funding: Aston University Research Studentship

Keywords

  • Oxazoles
  • Scintillation
  • SPA

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