TY - JOUR
T1 - Synthesis, evaluation and incorporation into liposomes of 4-functionalised-2,5-diphenyloxazole derivatives for application in scintillation proximity assays
AU - McCairn, Mark C.
AU - Culliford, Steven J.
AU - Kozlowski, Roland Z.
AU - Sutherland, Andrew J.
N1 - Funding: Aston University Research Studentship
PY - 2004/3/1
Y1 - 2004/3/1
N2 - The preparation of a series of 4-functionalised-2,5-diphenyloxazoles is described. The scintillating efficiency of each of these 'scintilipid' molecules has been evaluated in the presence of ionising radiation. Each 'scintilipid' has been assessed for the ability to assemble, with other lipids, into liposomes, under a variety of preparative conditions. Each liposomal preparation has been monitored for the ability to scintillate in the presence of ionising radiation. The optimal 'scintilipid', both in terms of effective liposomal formation and scintillation efficiency, has been determined.
AB - The preparation of a series of 4-functionalised-2,5-diphenyloxazoles is described. The scintillating efficiency of each of these 'scintilipid' molecules has been evaluated in the presence of ionising radiation. Each 'scintilipid' has been assessed for the ability to assemble, with other lipids, into liposomes, under a variety of preparative conditions. Each liposomal preparation has been monitored for the ability to scintillate in the presence of ionising radiation. The optimal 'scintilipid', both in terms of effective liposomal formation and scintillation efficiency, has been determined.
KW - Oxazoles
KW - Scintillation
KW - SPA
UR - http://www.scopus.com/inward/record.url?scp=1242340483&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S0040403904001030?via%3Dihub
U2 - 10.1016/j.tetlet.2004.01.034
DO - 10.1016/j.tetlet.2004.01.034
M3 - Article
AN - SCOPUS:1242340483
VL - 45
SP - 2163
EP - 2166
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 10
ER -