The ageing pancreas

James E. Brown

Research output: Contribution to journalArticlepeer-review


Type 2 diabetes is historically associated with older adults, and glucose tolerance is known to decline with advancing age. During the course of natural ageing, changes in many peripheral tissues contribute to this deterioration of glucose homeostasis. Included in this process are changes to the structure and function of the pancreatic islets, which undergo deviation in endocrine responses to glycaemic challenge. Current knowledge about the changes seen in the ageing pancreas is reviewed here.
Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalBritish Journal of Diabetes and Vascular Disease
Issue number3
Publication statusPublished - May 2012


  • ageing
  • pancreatic islets
  • β-cells


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