TY - JOUR
T1 - The clinical profile and associated mortality in people with and without diabetes with Coronavirus disease 2019 on admission to acute hospital services
AU - Gokhale, Krishna
AU - Mostafa, Samiul A.
AU - Wang, Jingya
AU - Tahrani, Abd A.
AU - Sainsbury, Christopher Andrew
AU - Toulis, Konstantinos A.
AU - Thomas, G. Neil
AU - Hassan‐Smith, Zaki
AU - Sapey, Elizabeth
AU - Gallier, Suzy
AU - Adderley, Nicola Jaime
AU - Narendran, Parth
AU - Bellary, Srikanth
AU - Taverner, Tom
AU - Ghosh, Sandip
AU - Nirantharakumar, Krishnarajah
AU - Hanif, Wasim
N1 - © 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
PY - 2022/1
Y1 - 2022/1
N2 - INTRODUCTION: To assess if in adults with COVID-19, whether those with diabetes and complications (DM+C) present with a more severe clinical profile and if that relates to increased mortality, compared to those with diabetes with no complications (DM-NC) and those without diabetes.METHODS: Service-level data was used from 996 adults with laboratory confirmed COVID-19 who presented to the Queen Elizabeth Hospital Birmingham, UK, from March to June 2020. All individuals were categorized into DM+C, DM-NC, and non-diabetes groups. Physiological and laboratory measurements in the first 5 days after admission were collated and compared among groups. Cox proportional hazards regression models were used to evaluate associations between diabetes status and the risk of mortality.RESULTS: Among the 996 individuals, 104 (10.4%) were DM+C, 295 (29.6%) DM-NC and 597 (59.9%) non-diabetes. There were 309 (31.0%) in-hospital deaths documented, 40 (4.0% of total cohort) were DM+C, 99 (9.9%) DM-NC and 170 (17.0%) non-diabetes. Individuals with DM+C were more likely to present with high anion gap/metabolic acidosis, features of renal impairment, and low albumin/lymphocyte count than those with DM-NC or those without diabetes. There was no significant difference in mortality rates among the groups: compared to individuals without diabetes, the adjusted HRs were 1.39 (95% CI 0.95-2.03, p = 0.093) and 1.18 (95% CI 0.90-1.54, p = 0.226) in DM+C and DM-C, respectively.CONCLUSIONS: Those with COVID-19 and DM+C presented with a more severe clinical and biochemical profile, but this did not associate with increased mortality in this study.
AB - INTRODUCTION: To assess if in adults with COVID-19, whether those with diabetes and complications (DM+C) present with a more severe clinical profile and if that relates to increased mortality, compared to those with diabetes with no complications (DM-NC) and those without diabetes.METHODS: Service-level data was used from 996 adults with laboratory confirmed COVID-19 who presented to the Queen Elizabeth Hospital Birmingham, UK, from March to June 2020. All individuals were categorized into DM+C, DM-NC, and non-diabetes groups. Physiological and laboratory measurements in the first 5 days after admission were collated and compared among groups. Cox proportional hazards regression models were used to evaluate associations between diabetes status and the risk of mortality.RESULTS: Among the 996 individuals, 104 (10.4%) were DM+C, 295 (29.6%) DM-NC and 597 (59.9%) non-diabetes. There were 309 (31.0%) in-hospital deaths documented, 40 (4.0% of total cohort) were DM+C, 99 (9.9%) DM-NC and 170 (17.0%) non-diabetes. Individuals with DM+C were more likely to present with high anion gap/metabolic acidosis, features of renal impairment, and low albumin/lymphocyte count than those with DM-NC or those without diabetes. There was no significant difference in mortality rates among the groups: compared to individuals without diabetes, the adjusted HRs were 1.39 (95% CI 0.95-2.03, p = 0.093) and 1.18 (95% CI 0.90-1.54, p = 0.226) in DM+C and DM-C, respectively.CONCLUSIONS: Those with COVID-19 and DM+C presented with a more severe clinical and biochemical profile, but this did not associate with increased mortality in this study.
KW - COVID-19
KW - complications
KW - diabetes
KW - SARS-CoV-2
KW - Hospitals
KW - Humans
KW - Risk Factors
KW - Adult
KW - Retrospective Studies
KW - Diabetes Mellitus
UR - https://onlinelibrary.wiley.com/doi/10.1002/edm2.309
UR - http://www.scopus.com/inward/record.url?scp=85120413969&partnerID=8YFLogxK
U2 - 10.1002/edm2.309
DO - 10.1002/edm2.309
M3 - Article
C2 - 34859617
SN - 2398-9238
VL - 5
JO - Endocrinology, Diabetes & Metabolism
JF - Endocrinology, Diabetes & Metabolism
IS - 1
M1 - e00309
ER -