The effect of simulated cataract light scatter on retinal vessel oximetry

Sunni R. Patel; Chris Hudson; John G. Flanagan; Rebekka Heitmar

doi:10.1016/j.exer.2013.09.004

The effect of simulated cataract light scatter on retinal vessel oximetry

Sunni R. Patel^*, Chris Hudson, John G. Flanagan, Rebekka Heitmar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. © 2013 Elsevier Ltd.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Experimental Eye Research
Volume	116
Early online date	19 Sept 2013
DOIs	https://doi.org/10.1016/j.exer.2013.09.004
Publication status	Published - Nov 2013

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Experimental eye research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Patel, SR, Hudson, C, Flanagan, JG & Heitmar, R, 'The effect of simulated cataract light scatter on retinal vessel oximetry' Experimental eye research, vol. 116 (2013) DOI http://dx.doi.org/10.1016/j.exer.2013.09.004

Keywords

cataract models
extraneous factors
light scatter
retinal oximetry
retinal oxygenation

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10.1016/j.exer.2013.09.004

Effect of simulated cataract light scatter on retinal vessel oximetry
NOTICE: this is the author’s version of a work that was accepted for publication in Experimental eye research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Patel, SR, Hudson, C, Flanagan, JG & Heitmar, R, 'The effect of simulated cataract light scatter on retinal vessel oximetry' Experimental eye research, vol. 116 (2013) DOI http://dx.doi.org/10.1016/j.exer.2013.09.004
Accepted author manuscript, 125 KB

Cite this

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title = "The effect of simulated cataract light scatter on retinal vessel oximetry",

abstract = "To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. {\textcopyright} 2013 Elsevier Ltd.",

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N2 - To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. © 2013 Elsevier Ltd.

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ER -

The effect of simulated cataract light scatter on retinal vessel oximetry

Abstract

Bibliographical note

Keywords

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