The first experience in estimation of basal cell carcinoma cryoresistence using noninvasive spectrophotometry

V. V. Andrukhina, K. S. Litvinova, A. A. Nikitin, N. Z. Spiridonova, D. A. Rogatkin

Research output: Contribution to journalConference articlepeer-review


The urgency of BCC study affecting maxillofacial area and neck is not only caused by high prevalence of this disease, but also insufficient efficiency of existing treatment methods which lead to full or partial recovery only in 60-80% of cases. We analyzed the results of 198 BCC cases cryosurgical treatment. 33 (16,6%) patients showed continued tumor growth. It has been hypothesized that the behavior and character of microcirculation changes during patient's testing have to correlate with damaging rate of tumors that will allow to develop indications for surgical treatment with local destruction - cryosurgery or cryolaser treatment. We have tested the new group of 33 patients with primary and recurrence types of basal cell carcinoma (BCC) by means of Laser Doppler Flowmetry, Tissues Reflectance Oximetry, Laser Fluorescence Diagnostics before operation. It was shown that the microcirculatory data indicates the presence of cryoresistance.

Original languageEnglish
Article number75470G
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 11 Feb 2010
EventSaratov Fall Meeting 2009 - International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics - Saratov, Russian Federation
Duration: 21 Sept 200924 Sept 2009


  • BCC
  • Cryosurgery
  • In vivo
  • Laser Doppler Flowmetry
  • Noninvasive
  • Spectrophotometry


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