The flavonoid galangin inhibits the L1 metallo-β-lactamase from Stenotrophomonas maltophilia

Brian J. Denny; Peter A. Lambert; Patrick W J West

doi:10.1016/S0378-1097(01)00580-8

The flavonoid galangin inhibits the L1 metallo-β-lactamase from Stenotrophomonas maltophilia

Brian J. Denny^*, Peter A. Lambert, Patrick W J West

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The flavonoid galangin inhibits the partially purified metallo-β-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl₂ suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	208
Issue number	1
DOIs	https://doi.org/10.1016/S0378-1097(01)00580-8
Publication status	Published - 19 Feb 2002

Keywords

Flavonoid
Galangin
Metallo-β-lactamase
Molecular modelling
Stenotrophomonas maltophilia

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10.1016/S0378-1097(01)00580-8

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abstract = "The flavonoid galangin inhibits the partially purified metallo-β-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl2 suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.",

keywords = "Flavonoid, Galangin, Metallo-β-lactamase, Molecular modelling, Stenotrophomonas maltophilia",

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AU - West, Patrick W J

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N2 - The flavonoid galangin inhibits the partially purified metallo-β-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl2 suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.

AB - The flavonoid galangin inhibits the partially purified metallo-β-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl2 suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.

KW - Flavonoid

KW - Galangin

KW - Metallo-β-lactamase

KW - Molecular modelling

KW - Stenotrophomonas maltophilia

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JF - FEMS Microbiology Letters

IS - 1

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The flavonoid galangin inhibits the L1 metallo-β-lactamase from Stenotrophomonas maltophilia

Abstract

Keywords

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