TY - JOUR
T1 - The influence of mouse Ped gene expression on postnatal development
AU - Watkins, Adam
AU - Wilkins, Adrian
AU - Osmond, Clive
AU - Warner, Carol M.
AU - Comiskey, Martina
AU - Hanson, Mark
AU - Fleming, Tom P.
PY - 2006/2/15
Y1 - 2006/2/15
N2 - The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P
AB - The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P
UR - http://www.scopus.com/inward/record.url?scp=33645866472&partnerID=8YFLogxK
UR - http://jp.physoc.org/content/571/1/211
U2 - 10.1113/jphysiol.2005.099192
DO - 10.1113/jphysiol.2005.099192
M3 - Article
AN - SCOPUS:33645866472
SN - 0022-3751
VL - 571
SP - 211
EP - 220
JO - Journal of Physiology
JF - Journal of Physiology
ER -