The pharmacology of CGRP-responsive receptors in cultured and transfected cells

D.L. Hay, A.C. Conner, S.G. Howitt, M.A. Takhshid, J. Simms, K. Mahmoud, David Poyner

Research output: Contribution to journalArticlepeer-review


Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.
Original languageEnglish
Pages (from-to)2019-2026
Number of pages8
Issue number11
Publication statusPublished - 1 Nov 2004


  • CGRP
  • calcitonin receptor-like receptor
  • RAMP1
  • RAMP2
  • RAMP3
  • CL
  • CGRP8–37
  • calcitonin receptor
  • BIBN4096BS


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