The regulation of bacterial transcription initiation

Douglas F Browning; Stephen J Busby

doi:10.1038/nrmicro787

The regulation of bacterial transcription initiation

Research output: Contribution to journal › Review article › peer-review

Abstract

Bacteria use their genetic material with great effectiveness to make the right products in the correct amounts at the appropriate time. Studying bacterial transcription initiation in Escherichia coli has served as a model for understanding transcriptional control throughout all kingdoms of life. Every step in the pathway between gene and function is exploited to exercise this control, but for reasons of economy, it is plain that the key step to regulate is the initiation of RNA-transcript formation.

Original language	English
Pages (from-to)	57-65
Number of pages	9
Journal	Nature Reviews: Microbiology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1038/nrmicro787
Publication status	Published - 1 Jan 2004

Keywords

Bacteria/genetics
Bacterial Proteins/genetics
Escherichia coli/genetics
Gene Expression Regulation, Bacterial
Promoter Regions, Genetic
Transcription, Genetic

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10.1038/nrmicro787

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abstract = "Bacteria use their genetic material with great effectiveness to make the right products in the correct amounts at the appropriate time. Studying bacterial transcription initiation in Escherichia coli has served as a model for understanding transcriptional control throughout all kingdoms of life. Every step in the pathway between gene and function is exploited to exercise this control, but for reasons of economy, it is plain that the key step to regulate is the initiation of RNA-transcript formation.",

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AB - Bacteria use their genetic material with great effectiveness to make the right products in the correct amounts at the appropriate time. Studying bacterial transcription initiation in Escherichia coli has served as a model for understanding transcriptional control throughout all kingdoms of life. Every step in the pathway between gene and function is exploited to exercise this control, but for reasons of economy, it is plain that the key step to regulate is the initiation of RNA-transcript formation.

KW - Bacteria/genetics

KW - Bacterial Proteins/genetics

KW - Escherichia coli/genetics

KW - Gene Expression Regulation, Bacterial

KW - Promoter Regions, Genetic

KW - Transcription, Genetic

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The regulation of bacterial transcription initiation

Abstract

Keywords

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