@inproceedings{33d3e4edd8934b7b8dc189e12173c951,
title = "The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease",
abstract = "Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincar{\'e} sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.",
keywords = "Alzheimer's, Amyloid-{\ss} plaque, Anisotropy, Depolarization, Scattering, Statistical analysis",
author = "Mariia Borovkova and Alexander Bykov and Alexey Popov and Angelo Pierangelo and Tatiana Novikova and Jens Pahnke and Igor Meglinski",
note = "Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. ; Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020 ; Conference date: 02-02-2020 Through 05-02-2020",
year = "2020",
month = feb,
day = "21",
doi = "10.1117/12.2550795",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Alfano, {Robert R.} and Demos, {Stavros G.} and Seddon, {Angela B.}",
booktitle = "Optical Biopsy XVIII",
address = "United States",
}