Thiazolidinediones

Clifford J. Bailey*

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review

Abstract

Thiazolidinediones (TZDs), also termed "glitazones", are used as antidiabetic agents for the treatment of type 2 (non-insulin dependent) diabetes mellitus. They activate the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma). This increases the transcription of various insulin-sensitive genes, improving insulin action and lowering blood glucose concentrations. TZDs currently in clinical use for the treatment of type 2 diabetes are rosiglitazone and pioglitazone. Troglitazone was withdrawn due to hepatotoxicity. Other TZDs (e.g. ciglitazone) have been studied preclinically, but not introduced into clinical use. TZDs do not cause severe hypoglycemia, hence they are regarded as antihyperglycemic (rather than hypoglycemic) agents ....

Original languageEnglish
Title of host publicationxPharm
Subtitle of host publicationthe comprehensive pharmacology reference
EditorsS.J. Enna, David B. Bylund
PublisherElsevier
Number of pages2
ISBN (Print)978-0-08-055232-3
DOIs
Publication statusPublished - Feb 2011

Bibliographical note

Updated by C.J. Bailey, Thiazolidinediones, Reference Module in Biomedical Sciences, 2015.

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  • Biguanides

    Day, C. & Bailey, C. J., Feb 2011, xPharm: the comprehensive pharmacology reference. Enna, S. J. & Bylund, D. B. (eds.). Elsevier, 3 p.

    Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review

  • Ciglitazone

    Day, C. & Bailey, C. J., Feb 2011, xPharm: the comprehensive pharmacology reference. Enna, S. J. & Bylund, D. B. (eds.). Elsevier, 2 p.

    Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review

  • Metformin

    Day, C. & Bailey, C. J., 1 Dec 2011, xPharm: the comprehensive pharmacology reference. Enna, S. J. & Bylund, D. B. (eds.). Elsevier, 4 p.

    Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review

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