Thiol redox homeostasis in neurodegenerative disease

Gethin J. McBean; Mutay Aslan; Helen R. Griffiths; Rita C Torrão

doi:10.1016/j.redox.2015.04.004

Thiol redox homeostasis in neurodegenerative disease

Gethin J. McBean^*, Mutay Aslan, Helen R. Griffiths, Rita C Torrão

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the x_c^- cystine-glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed.

Original language	English
Pages (from-to)	186-194
Number of pages	9
Journal	Redox biology
Volume	5
Early online date	22 Apr 2015
DOIs	https://doi.org/10.1016/j.redox.2015.04.004
Publication status	Published - Aug 2015

Bibliographical note

© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Supported by the European Cooperation In Science and Technology (COST) Action BM1203, EU-ROS.

Keywords

cysteine
glutathione
thioredoxin
glutaredoxin
peroxiredoxin
neurodegenerative disease

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10.1016/j.redox.2015.04.004

Thiol redox homeostasis in neurodegenerative disease
© 2015 The Authors. Published by Elsevier B.V. This is an open access article underthe CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Accepted author manuscript, 1.08 MBLicence: CC BY-NC-ND 3.0

Cite this

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KW - cysteine

KW - glutathione

KW - thioredoxin

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KW - peroxiredoxin

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Thiol redox homeostasis in neurodegenerative disease

Abstract

Bibliographical note

Keywords

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