Through-thickness plasma modification of biodegradable and nonbiodegradable porous polymer constructs

Laleh Sahnia, Karen Wilson, Athanasios Mantalaris, Alexander Bismarck

Research output: Contribution to journalArticlepeer-review


Pure poly(lactide-co-glycolide) and polystyrene surfaces are not very suitable to support cell adhesion/ spreading owing to their hydrophobic nature and low surface energy. The interior surfaces of large porous 3D scaffolds were modified and activated using radio-frequency, low-pressure air plasma. An increase in the wettability of the surface was observed after exposure to air plasma, as indicated by the decrease in the contact angles of the wet porous system. The surface composition of the plasma-treated polymers was studied using X-ray photoelectron spectroscopy. pH-dependent zeta-potential measurements confirm the presence of an increased number of functional groups. However, the plasma-treated surfaces have a less acidic character than the original polymer surfaces as seen by a shift in their isoelectric point. Zeta-potential, as well as contact angle measurements, on 3D scaffolds confirm that plasma treatment is a useful tool to modify the surface properties throughout the interior of large scaffolds.
Original languageEnglish
Pages (from-to)632-642
Number of pages11
JournalJournal of Biomedical Materials Research: Part A
Issue number3
Early online date11 Jan 2008
Publication statusPublished - 1 Dec 2008


  • biomaterials
  • modification
  • surfaces
  • foams
  • atmospheric pressure plasma
  • low-pressure plasma
  • poly (lactic-co-glycolic acid)
  • polystyrene


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