Tissue transglutaminase and the stress response

R. Ientile*, D. Caccamo, Martin Griffin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The expression of the protein crosslinking enzyme tissue transglutaminase (TG2, tTG), the ubiquitous member of transglutaminase family, can be regulated by multiple factors. Although it has been suggested that TG2 can be involved in apoptotic cell death, high levels of enzyme have also been associated with cell survival in response to different stimuli. Furthermore, evidence indicates that increases in TG2 production cause enzyme translocation to cell membrane. Cell stress can also lead to TG2 accumulation on the cell surface and in the extracellular matrix resulting in changes in cell-matrix interactions. Here, we discuss the underlying mechanisms of TG2 up-regulation induced by various stimuli including glutamate exposure, calcium influx, oxidative stress, UV, and inflammatory cytokines. These findings agree with a postulated role for transglutaminases in molecular mechanisms involved in several diseases suggesting that cross-linking reactions could be a relevant part of the biochemical changes observed in pathological conditions. © 2007 Springer-Verlag.

Original languageEnglish
Pages (from-to)385-394
Number of pages10
JournalAmino Acids
Issue number2
Publication statusPublished - Aug 2007


  • extracellular matrix
  • inflammation
  • neurodegeneration
  • oxidative stress
  • tissue transglutaminase
  • transglutaminases


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