Abstract
In this study, porous polymers with nitrogen heterocyclic core structures are synthesized through the condensation of enaminonitrile and terephthalaldehyde monomers. These polymers are used as a platform to store bioactive nitric oxide (NO) and control its release. NO loading is achieved by nitrosating the polymers with acidified nitrite, a process that also imparts photoresponsivity to the polymers. Polymer composition and porosity affect NO storage and release. It is observed that under UV light at 365 nm in a PBS solution, the polymers (NO@DHP-POP) can release NO in a manner fully controlled by UV lighting. Under experimental conditions, these porous polymers release NO at a rate of ≈10.0–50.0 µmol g −1 over 60 min. These findings demonstrate the potential of these polymers for integrating NO delivery into phototherapy applications.
| Original language | English |
|---|---|
| Article number | 2400142 |
| Number of pages | 6 |
| Journal | Macromolecular rapid communications |
| Early online date | 27 Jun 2024 |
| DOIs | |
| Publication status | E-pub ahead of print - 27 Jun 2024 |
Bibliographical note
Copyright © 2024 The Author(s). Macromolecular Rapid Communications published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Keywords
- light irradiation
- nitric oxide
- nitrosation
- photoresponsiveness
- porous polymer