Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads

Alexander C. Perino; Paul J. Wang; Michael Lloyd; Francesco Zanon; Katsuhito Fujiu; Faizel Osman; Sem Briongos-Figuero; Toshiaki Sato; Tolga Aksu; Marek Jastrzebski; Skevos Sideris; Praveen Rao; Krzysztof Boczar; Xu Yuan-Ning; Michael Wu; Narayanan Namboodiri; Rodrigue Garcia; Vikas Kataria; Jan De pooter; Oliver Przibille; Anil K. Gehi; Oscar Cano; Grigorios Katsouras; Binni Cai; Klaus Astheimer; Tanyanan Tanawuttiwat; Tomas Datino; Jacques Rizkallah; Mohammad Alasti; Gregory Feld; Maria Teresa Barrio-Lopez; Mark Gilmore; Sergio Conti; Satoshi Yanagisawa; Julia H. Indik; Jiangang Zou; Sandeep A. Saha; Daniel Rodriguez-Munoz; Kuan-cheng Chang; Dmitry S. Lebedev; Miguel A. Leal; Andreas Haeberlin; Alexander R. J. Dal Forno; Michael Orlov; Manuel Frutos; Pilar Cabanas-Grandio; Jonathan Lyne; Francisco Leyva; Jose Maria Tolosana; Pierre Ollitrault; Pasquale Vergara; Cristina Balla; Subodh R. Devabhaktuni; Giovanni Forleo; Konstantinos P. Letsas; Atul Verma; Jeffrey P. Moak; Abhijeet B. Shelke; Karol Curila; Edmond M. Cronin; Piotr Futyma; Elaine Y. Wan; Pietro Enea Lazzerini; Felipe Bisbal; Michela Casella; Gioia Turitto; Lawrence Rosenthal; T. Jared Bunch; Artur Baszko; Nicolas Clementy; Yong-mei Cha; Huang-chung Chen; Vincent Galand; Robert Schaller; Julian W. E. Jarman; Masahide Harada; Yong Wei; Kengo Kusano; Constanze Schmidt; Marco Antonio Arguello Hurtado; Niyada Naksuk; Tadashi Hoshiyama; Krishna Kancharla; Yoji Iida; Mashiro Mizobuchi; Daniel P. Morin; Serkan Cay; Gabriele Paglino; Tillman Dahme; Sharad Agarwal; Pugazhendhi Vijayaraman; Parikshit S. Sharma

doi:10.1007/s10840-022-01417-4

Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads

Alexander C. Perino, Paul J. Wang, Michael Lloyd, Francesco Zanon, Katsuhito Fujiu, Faizel Osman, Sem Briongos-Figuero, Toshiaki Sato, Tolga Aksu, Marek Jastrzebski, Skevos Sideris, Praveen Rao, Krzysztof Boczar, Xu Yuan-Ning, Michael Wu, Narayanan Namboodiri, Rodrigue Garcia, Vikas Kataria, Jan De pooter, Oliver PrzibilleAnil K. Gehi, Oscar Cano, Grigorios Katsouras, Binni Cai, Klaus Astheimer, Tanyanan Tanawuttiwat, Tomas Datino, Jacques Rizkallah, Mohammad Alasti, Gregory Feld, Maria Teresa Barrio-Lopez, Mark Gilmore, Sergio Conti, Satoshi Yanagisawa, Julia H. Indik, Jiangang Zou, Sandeep A. Saha, Daniel Rodriguez-Munoz, Kuan-cheng Chang, Dmitry S. Lebedev, Miguel A. Leal, Andreas Haeberlin, Alexander R. J. Dal Forno, Michael Orlov, Manuel Frutos, Pilar Cabanas-Grandio, Jonathan Lyne, Francisco Leyva, Jose Maria Tolosana, Pierre Ollitrault, Pasquale Vergara, Cristina Balla, Subodh R. Devabhaktuni, Giovanni Forleo, Konstantinos P. Letsas, Atul Verma, Jeffrey P. Moak, Abhijeet B. Shelke, Karol Curila, Edmond M. Cronin, Piotr Futyma, Elaine Y. Wan, Pietro Enea Lazzerini, Felipe Bisbal, Michela Casella, Gioia Turitto, Lawrence Rosenthal, T. Jared Bunch, Artur Baszko, Nicolas Clementy, Yong-mei Cha, Huang-chung Chen, Vincent Galand, Robert Schaller, Julian W. E. Jarman, Masahide Harada, Yong Wei, Kengo Kusano, Constanze Schmidt, Marco Antonio Arguello Hurtado, Niyada Naksuk, Tadashi Hoshiyama, Krishna Kancharla, Yoji Iida, Mashiro Mizobuchi, Daniel P. Morin, Serkan Cay, Gabriele Paglino, Tillman Dahme, Sharad Agarwal, Pugazhendhi Vijayaraman, Parikshit S. Sharma

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Adoption and outcomes for conduction system pacing (CSP), which includes His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), in real-world settings are incompletely understood. We sought to describe real-world adoption of CSP lead implantation and subsequent outcomes.

METHODS: We performed an online cross-sectional survey on the implantation and outcomes associated with CSP, between November 15, 2020, and February 15, 2021. We described survey responses and reported HBP and LBBAP outcomes for bradycardia pacing and cardiac resynchronization CRT indications, separately.

RESULTS: The analysis cohort included 140 institutions, located on 5 continents, who contributed data to the worldwide survey on CSP. Of these, 127 institutions (90.7%) reported experience implanting CSP leads. CSP and overall device implantation volumes were reported by 84 institutions. In 2019, the median proportion of device implants with CSP, HBP, and/or LBBAP leads attempted were 4.4% (interquartile range [IQR], 1.9-12.5%; range, 0.4-100%), 3.3% (IQR, 1.3-7.1%; range, 0.2-87.0%), and 2.5% (IQR, 0.5-24.0%; range, 0.1-55.6%), respectively. For bradycardia pacing indications, HBP leads, as compared to LBBAP leads, had higher reported implant threshold (median [IQR]: 1.5 V [1.3-2.0 V] vs 0.8 V [0.6-1.0 V], p = 0.0008) and lower ventricular sensing (median [IQR]: 4.0 mV [3.0-5.0 mV] vs. 10.0 mV [7.0-12.0 mV], p < 0.0001).

CONCLUSION: In conclusion, CSP lead implantation has been broadly adopted but has yet to become the default approach at most surveyed institutions. As the indications and data for CSP continue to evolve, strategies to educate and promote CSP lead implantation at institutions without CSP lead implantation experience would be necessary.

Original language	English
Pages (from-to)	1589-1600
Number of pages	12
Journal	Journal of Interventional Cardiac Electrophysiology
Volume	66
Issue number	7
Early online date	6 Jan 2023
DOIs	https://doi.org/10.1007/s10840-022-01417-4
Publication status	Published - Oct 2023

Bibliographical note

Funding Information:
The Stanford REDCap platform (http://redcap.stanford.edu) is developed and operated by Stanford Medicine Research IT team. The REDCap platform services at Stanford are subsidized by (a) Stanford School of Medicine Research Office and (b) the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through grant UL1 TR001085. A complete list of institutions and survey respondents contributing data to the worldwide survey on conduction system pacing is available in the supplemental material.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Conduction system pacing
His bundle pacing
Left bundle branch area pacing

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10.1007/s10840-022-01417-4

Cite this

Perino, A. C., Wang, P. J., Lloyd, M., Zanon, F., Fujiu, K., Osman, F., Briongos-Figuero, S., Sato, T., Aksu, T., Jastrzebski, M., Sideris, S., Rao, P., Boczar, K., Yuan-Ning, X., Wu, M., Namboodiri, N., Garcia, R., Kataria, V., De pooter, J., ... Sharma, P. S. (2023). Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads. Journal of Interventional Cardiac Electrophysiology, 66(7), 1589-1600. https://doi.org/10.1007/s10840-022-01417-4

@article{3f4cd5cb98cb45169cf6e85db45baec2,

title = "Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads",

abstract = "BACKGROUND: Adoption and outcomes for conduction system pacing (CSP), which includes His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), in real-world settings are incompletely understood. We sought to describe real-world adoption of CSP lead implantation and subsequent outcomes.METHODS: We performed an online cross-sectional survey on the implantation and outcomes associated with CSP, between November 15, 2020, and February 15, 2021. We described survey responses and reported HBP and LBBAP outcomes for bradycardia pacing and cardiac resynchronization CRT indications, separately.RESULTS: The analysis cohort included 140 institutions, located on 5 continents, who contributed data to the worldwide survey on CSP. Of these, 127 institutions (90.7%) reported experience implanting CSP leads. CSP and overall device implantation volumes were reported by 84 institutions. In 2019, the median proportion of device implants with CSP, HBP, and/or LBBAP leads attempted were 4.4% (interquartile range [IQR], 1.9-12.5%; range, 0.4-100%), 3.3% (IQR, 1.3-7.1%; range, 0.2-87.0%), and 2.5% (IQR, 0.5-24.0%; range, 0.1-55.6%), respectively. For bradycardia pacing indications, HBP leads, as compared to LBBAP leads, had higher reported implant threshold (median [IQR]: 1.5 V [1.3-2.0 V] vs 0.8 V [0.6-1.0 V], p = 0.0008) and lower ventricular sensing (median [IQR]: 4.0 mV [3.0-5.0 mV] vs. 10.0 mV [7.0-12.0 mV], p < 0.0001).CONCLUSION: In conclusion, CSP lead implantation has been broadly adopted but has yet to become the default approach at most surveyed institutions. As the indications and data for CSP continue to evolve, strategies to educate and promote CSP lead implantation at institutions without CSP lead implantation experience would be necessary.",

keywords = "Conduction system pacing, His bundle pacing, Left bundle branch area pacing",

author = "Perino, {Alexander C.} and Wang, {Paul J.} and Michael Lloyd and Francesco Zanon and Katsuhito Fujiu and Faizel Osman and Sem Briongos-Figuero and Toshiaki Sato and Tolga Aksu and Marek Jastrzebski and Skevos Sideris and Praveen Rao and Krzysztof Boczar and Xu Yuan-Ning and Michael Wu and Narayanan Namboodiri and Rodrigue Garcia and Vikas Kataria and {De pooter}, Jan and Oliver Przibille and Gehi, {Anil K.} and Oscar Cano and Grigorios Katsouras and Binni Cai and Klaus Astheimer and Tanyanan Tanawuttiwat and Tomas Datino and Jacques Rizkallah and Mohammad Alasti and Gregory Feld and Barrio-Lopez, {Maria Teresa} and Mark Gilmore and Sergio Conti and Satoshi Yanagisawa and Indik, {Julia H.} and Jiangang Zou and Saha, {Sandeep A.} and Daniel Rodriguez-Munoz and Kuan-cheng Chang and Lebedev, {Dmitry S.} and Leal, {Miguel A.} and Andreas Haeberlin and Forno, {Alexander R. J. Dal} and Michael Orlov and Manuel Frutos and Pilar Cabanas-Grandio and Jonathan Lyne and Francisco Leyva and Tolosana, {Jose Maria} and Pierre Ollitrault and Pasquale Vergara and Cristina Balla and Devabhaktuni, {Subodh R.} and Giovanni Forleo and Letsas, {Konstantinos P.} and Atul Verma and Moak, {Jeffrey P.} and Shelke, {Abhijeet B.} and Karol Curila and Cronin, {Edmond M.} and Piotr Futyma and Wan, {Elaine Y.} and Lazzerini, {Pietro Enea} and Felipe Bisbal and Michela Casella and Gioia Turitto and Lawrence Rosenthal and Bunch, {T. Jared} and Artur Baszko and Nicolas Clementy and Yong-mei Cha and Huang-chung Chen and Vincent Galand and Robert Schaller and Jarman, {Julian W. E.} and Masahide Harada and Yong Wei and Kengo Kusano and Constanze Schmidt and Hurtado, {Marco Antonio Arguello} and Niyada Naksuk and Tadashi Hoshiyama and Krishna Kancharla and Yoji Iida and Mashiro Mizobuchi and Morin, {Daniel P.} and Serkan Cay and Gabriele Paglino and Tillman Dahme and Sharad Agarwal and Pugazhendhi Vijayaraman and Sharma, {Parikshit S.}",

note = "Funding Information: The Stanford REDCap platform (http://redcap.stanford.edu) is developed and operated by Stanford Medicine Research IT team. The REDCap platform services at Stanford are subsidized by (a) Stanford School of Medicine Research Office and (b) the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through grant UL1 TR001085. A complete list of institutions and survey respondents contributing data to the worldwide survey on conduction system pacing is available in the supplemental material. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2023",

month = oct,

doi = "10.1007/s10840-022-01417-4",

language = "English",

volume = "66",

pages = "1589--1600",

number = "7",

}

Perino, AC, Wang, PJ, Lloyd, M, Zanon, F, Fujiu, K, Osman, F, Briongos-Figuero, S, Sato, T, Aksu, T, Jastrzebski, M, Sideris, S, Rao, P, Boczar, K, Yuan-Ning, X, Wu, M, Namboodiri, N, Garcia, R, Kataria, V, De pooter, J, Przibille, O, Gehi, AK, Cano, O, Katsouras, G, Cai, B, Astheimer, K, Tanawuttiwat, T, Datino, T, Rizkallah, J, Alasti, M, Feld, G, Barrio-Lopez, MT, Gilmore, M, Conti, S, Yanagisawa, S, Indik, JH, Zou, J, Saha, SA, Rodriguez-Munoz, D, Chang, K, Lebedev, DS, Leal, MA, Haeberlin, A, Forno, ARJD, Orlov, M, Frutos, M, Cabanas-Grandio, P, Lyne, J, Leyva, F, Tolosana, JM, Ollitrault, P, Vergara, P, Balla, C, Devabhaktuni, SR, Forleo, G, Letsas, KP, Verma, A, Moak, JP, Shelke, AB, Curila, K, Cronin, EM, Futyma, P, Wan, EY, Lazzerini, PE, Bisbal, F, Casella, M, Turitto, G, Rosenthal, L, Bunch, TJ, Baszko, A, Clementy, N, Cha, Y, Chen, H, Galand, V, Schaller, R, Jarman, JWE, Harada, M, Wei, Y, Kusano, K, Schmidt, C, Hurtado, MAA, Naksuk, N, Hoshiyama, T, Kancharla, K, Iida, Y, Mizobuchi, M, Morin, DP, Cay, S, Paglino, G, Dahme, T, Agarwal, S, Vijayaraman, P & Sharma, PS 2023, 'Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads', Journal of Interventional Cardiac Electrophysiology, vol. 66, no. 7, pp. 1589-1600. https://doi.org/10.1007/s10840-022-01417-4

TY - JOUR

T1 - Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads

AU - Perino, Alexander C.

AU - Wang, Paul J.

AU - Lloyd, Michael

AU - Zanon, Francesco

AU - Fujiu, Katsuhito

AU - Osman, Faizel

AU - Briongos-Figuero, Sem

AU - Sato, Toshiaki

AU - Aksu, Tolga

AU - Jastrzebski, Marek

AU - Sideris, Skevos

AU - Rao, Praveen

AU - Boczar, Krzysztof

AU - Yuan-Ning, Xu

AU - Wu, Michael

AU - Namboodiri, Narayanan

AU - Garcia, Rodrigue

AU - Kataria, Vikas

AU - De pooter, Jan

AU - Przibille, Oliver

AU - Gehi, Anil K.

AU - Cano, Oscar

AU - Katsouras, Grigorios

AU - Cai, Binni

AU - Astheimer, Klaus

AU - Tanawuttiwat, Tanyanan

AU - Datino, Tomas

AU - Rizkallah, Jacques

AU - Alasti, Mohammad

AU - Feld, Gregory

AU - Barrio-Lopez, Maria Teresa

AU - Gilmore, Mark

AU - Conti, Sergio

AU - Yanagisawa, Satoshi

AU - Indik, Julia H.

AU - Zou, Jiangang

AU - Saha, Sandeep A.

AU - Rodriguez-Munoz, Daniel

AU - Chang, Kuan-cheng

AU - Lebedev, Dmitry S.

AU - Leal, Miguel A.

AU - Haeberlin, Andreas

AU - Forno, Alexander R. J. Dal

AU - Orlov, Michael

AU - Frutos, Manuel

AU - Cabanas-Grandio, Pilar

AU - Lyne, Jonathan

AU - Leyva, Francisco

AU - Tolosana, Jose Maria

AU - Ollitrault, Pierre

AU - Vergara, Pasquale

AU - Balla, Cristina

AU - Devabhaktuni, Subodh R.

AU - Forleo, Giovanni

AU - Letsas, Konstantinos P.

AU - Verma, Atul

AU - Moak, Jeffrey P.

AU - Shelke, Abhijeet B.

AU - Curila, Karol

AU - Cronin, Edmond M.

AU - Futyma, Piotr

AU - Wan, Elaine Y.

AU - Lazzerini, Pietro Enea

AU - Bisbal, Felipe

AU - Casella, Michela

AU - Turitto, Gioia

AU - Rosenthal, Lawrence

AU - Bunch, T. Jared

AU - Baszko, Artur

AU - Clementy, Nicolas

AU - Cha, Yong-mei

AU - Chen, Huang-chung

AU - Galand, Vincent

AU - Schaller, Robert

AU - Jarman, Julian W. E.

AU - Harada, Masahide

AU - Wei, Yong

AU - Kusano, Kengo

AU - Schmidt, Constanze

AU - Hurtado, Marco Antonio Arguello

AU - Naksuk, Niyada

AU - Hoshiyama, Tadashi

AU - Kancharla, Krishna

AU - Iida, Yoji

AU - Mizobuchi, Mashiro

AU - Morin, Daniel P.

AU - Cay, Serkan

AU - Paglino, Gabriele

AU - Dahme, Tillman

AU - Agarwal, Sharad

AU - Vijayaraman, Pugazhendhi

AU - Sharma, Parikshit S.

N1 - Funding Information: The Stanford REDCap platform (http://redcap.stanford.edu) is developed and operated by Stanford Medicine Research IT team. The REDCap platform services at Stanford are subsidized by (a) Stanford School of Medicine Research Office and (b) the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through grant UL1 TR001085. A complete list of institutions and survey respondents contributing data to the worldwide survey on conduction system pacing is available in the supplemental material. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2023/10

Y1 - 2023/10

N2 - BACKGROUND: Adoption and outcomes for conduction system pacing (CSP), which includes His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), in real-world settings are incompletely understood. We sought to describe real-world adoption of CSP lead implantation and subsequent outcomes.METHODS: We performed an online cross-sectional survey on the implantation and outcomes associated with CSP, between November 15, 2020, and February 15, 2021. We described survey responses and reported HBP and LBBAP outcomes for bradycardia pacing and cardiac resynchronization CRT indications, separately.RESULTS: The analysis cohort included 140 institutions, located on 5 continents, who contributed data to the worldwide survey on CSP. Of these, 127 institutions (90.7%) reported experience implanting CSP leads. CSP and overall device implantation volumes were reported by 84 institutions. In 2019, the median proportion of device implants with CSP, HBP, and/or LBBAP leads attempted were 4.4% (interquartile range [IQR], 1.9-12.5%; range, 0.4-100%), 3.3% (IQR, 1.3-7.1%; range, 0.2-87.0%), and 2.5% (IQR, 0.5-24.0%; range, 0.1-55.6%), respectively. For bradycardia pacing indications, HBP leads, as compared to LBBAP leads, had higher reported implant threshold (median [IQR]: 1.5 V [1.3-2.0 V] vs 0.8 V [0.6-1.0 V], p = 0.0008) and lower ventricular sensing (median [IQR]: 4.0 mV [3.0-5.0 mV] vs. 10.0 mV [7.0-12.0 mV], p < 0.0001).CONCLUSION: In conclusion, CSP lead implantation has been broadly adopted but has yet to become the default approach at most surveyed institutions. As the indications and data for CSP continue to evolve, strategies to educate and promote CSP lead implantation at institutions without CSP lead implantation experience would be necessary.

AB - BACKGROUND: Adoption and outcomes for conduction system pacing (CSP), which includes His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), in real-world settings are incompletely understood. We sought to describe real-world adoption of CSP lead implantation and subsequent outcomes.METHODS: We performed an online cross-sectional survey on the implantation and outcomes associated with CSP, between November 15, 2020, and February 15, 2021. We described survey responses and reported HBP and LBBAP outcomes for bradycardia pacing and cardiac resynchronization CRT indications, separately.RESULTS: The analysis cohort included 140 institutions, located on 5 continents, who contributed data to the worldwide survey on CSP. Of these, 127 institutions (90.7%) reported experience implanting CSP leads. CSP and overall device implantation volumes were reported by 84 institutions. In 2019, the median proportion of device implants with CSP, HBP, and/or LBBAP leads attempted were 4.4% (interquartile range [IQR], 1.9-12.5%; range, 0.4-100%), 3.3% (IQR, 1.3-7.1%; range, 0.2-87.0%), and 2.5% (IQR, 0.5-24.0%; range, 0.1-55.6%), respectively. For bradycardia pacing indications, HBP leads, as compared to LBBAP leads, had higher reported implant threshold (median [IQR]: 1.5 V [1.3-2.0 V] vs 0.8 V [0.6-1.0 V], p = 0.0008) and lower ventricular sensing (median [IQR]: 4.0 mV [3.0-5.0 mV] vs. 10.0 mV [7.0-12.0 mV], p < 0.0001).CONCLUSION: In conclusion, CSP lead implantation has been broadly adopted but has yet to become the default approach at most surveyed institutions. As the indications and data for CSP continue to evolve, strategies to educate and promote CSP lead implantation at institutions without CSP lead implantation experience would be necessary.

KW - Conduction system pacing

KW - His bundle pacing

KW - Left bundle branch area pacing

UR - https://link.springer.com/article/10.1007/s10840-022-01417-4

UR - http://www.scopus.com/inward/record.url?scp=85145828205&partnerID=8YFLogxK

U2 - 10.1007/s10840-022-01417-4

DO - 10.1007/s10840-022-01417-4

M3 - Article

C2 - 36607529

AN - SCOPUS:85145828205

SN - 1383-875X

VL - 66

SP - 1589

EP - 1600

JO - Journal of Interventional Cardiac Electrophysiology

JF - Journal of Interventional Cardiac Electrophysiology

IS - 7

ER -

Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads

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